Evidence map›Paper›PMID 41555021›Full record

ArticleNature biotechnology2026

Engineered living glues secrete therapeutic proteins for treatment of inflammatory bowel disease.

Changhao Ge, Shanshan Jiang, Xiaomin Dong, Xiaoyu Jiang, Weiliang Zhi, Chenhao Yang, Yunqing Xiang, Chun Chu, Peilang Yang, Qian Zhang and 9 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Nature biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Changhao Ge *State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Key Laboratory of Materials Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Shanshan Jiang *Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, China.
Xiaomin DongState Key Laboratory of Quantitative Synthetic Biology, Shenzhen Key Laboratory of Materials Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Xiaoyu JiangSchool of Physical Science and Technology, ShanghaiTech University, Shanghai, China.
Weiliang ZhiSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Chenhao YangState Key Laboratory of Quantitative Synthetic Biology, Shenzhen Key Laboratory of Materials Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.ORCID http://orcid.org/0009-0000-0779-7911
Yunqing XiangState Key Laboratory of Quantitative Synthetic Biology, Shenzhen Key Laboratory of Materials Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Chun ChuState Key Laboratory of Quantitative Synthetic Biology, Shenzhen Key Laboratory of Materials Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Peilang YangDepartment of Burn, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qian ZhangState Key Laboratory of Quantitative Synthetic Biology, Shenzhen Key Laboratory of Materials Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Xin ChenMarshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, China.
Yan LiuDepartment of Burn, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shuqiang HuangState Key Laboratory of Quantitative Synthetic Biology, Shenzhen Key Laboratory of Materials Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Yifan LiuSchool of Physical Science and Technology, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0000-0002-2989-6280
Xiaoshan ShiState Key Laboratory of Quantitative Synthetic Biology, Shenzhen Key Laboratory of Materials Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.ORCID http://orcid.org/0000-0001-7931-8684
Jing LinMarshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, China.
Bolin AnState Key Laboratory of Quantitative Synthetic Biology, Shenzhen Key Laboratory of Materials Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. bl.an@siat.ac.cn.ORCID http://orcid.org/0009-0003-2750-2609
Peng HuangMarshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, China. peng.huang@szu.edu.cn.ORCID http://orcid.org/0000-0003-3651-7813
Chao ZhongState Key Laboratory of Quantitative Synthetic Biology, Shenzhen Key Laboratory of Materials Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. chao.zhong@siat.ac.cn.ORCID http://orcid.org/0000-0002-6638-3652

Funding

China Postdoctoral Science Foundation 2024M752123China Postdoctoral Science Foundation 2024T170582National Natural Science Foundation of China (National Science Foundation of China) 32201105National Natural Science Foundation of China (National Science Foundation of China) 32401222
6 · The paper itself

Abstract

Engineering bacteria to secrete gut therapeutics has been limited by their poor autonomous sensing of pathological cues and inability to sustain localized, long-term therapeutic activity. Here we engineer nonpathogenic Escherichia coli with a blood-inducible gene circuit that secretes the barnacle-derived adhesive protein CP43K and the therapeutic gut-barrier-healing factor TFF3 in response to gastrointestinal bleeding, an indicator of severe inflammatory bowel disease (IBD). Adhesive production enables sustained bacterial attachment to inflamed tissues for up to 10 days or 7 days following a single rectal or oral administration, respectively. This effect depends on bleeding-induced adhesion. Using two mouse models of IBD, the colitis model induced by dextran sulfate sodium and the interleukin-10-knockout mouse model, we demonstrate improved weight recovery, reversed colonic shortening and reduced intestinal bleeding. Additionally, the treatment decreases intestinal inflammation, promotes mucosal repair and restores gut barrier integrity, demonstrating comprehensive therapeutic efficacy.

Identifiers

PMID41555021

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.