ArticleNPJ precision oncology2026
Algorithm-assisted individualized therapy design improves survival in a mouse model of triple-negative breast cancer.
Article in NPJ precision oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Reframing cancer drug resistance: transporters, persister cells, senescence, and emerging therapeutic strategies.Magyar onkologia · 2026Review
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Authors and funding
11 authors.
Funding
Abstract
Chemotherapy remains indispensable in the treatment of malignant tumors but is often limited by the prevailing "one size fits all" approach, which neglects inter-patient variablity in pharmacokinetics and treatment response, often resulting in suboptimal outcomes. In this study, we explored individualized chemotherapy protocols in a clinically relevant mouse model of breast cancer using a novel algorithm-assisted therapy design (AATD). Two strategies were applied: a two-stage computational therapy protocol designed to stabilize blood concentrations of pegylated liposomal doxorubicin (PLD); and a model-predictive approach that optimizes dosing based on individual tumor characteristics. Compared to the standard maximum tolerated dose protocol, AATD-based personalized chemotherapy, guided by real-time monitoring of treatment response, tumor growth, and drug concentrations, significantly improved overall survival. Our findings in a mouse model of triple-negative breast cancer provide compelling evidence that chemotherapy can be personalized and optimized through algorithm-assisted therapy design.
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Registered trials
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