Quantitative assessment of age-related retinal and choriocapillaris blood flow changes in a healthy Korean population using optical coherence tomography angiography.

Young Hwan Jeong, Sang Cheol Yang, Tae Yeon Kim, No Hae Park, Sung Who Park, Iksoo Byon

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Young Hwan JeongDepartment of Ophthalmology, Biomedical Research Institute, Pusan National University Hospital, 179, Gudeok-ro, Seo-gu, Busan, 49241, South Korea.

Sang Cheol YangDepartment of Ophthalmology, Biomedical Research Institute, Pusan National University Hospital, 179, Gudeok-ro, Seo-gu, Busan, 49241, South Korea.

Tae Yeon KimDepartment of Ophthalmology, Biomedical Research Institute, Pusan National University Hospital, 179, Gudeok-ro, Seo-gu, Busan, 49241, South Korea.

No Hae ParkBaengnok Eye Clinic, Busan, South Korea.

Sung Who ParkDepartment of Ophthalmology, Biomedical Research Institute, Pusan National University Hospital, 179, Gudeok-ro, Seo-gu, Busan, 49241, South Korea.

Iksoo ByonDepartment of Ophthalmology, Biomedical Research Institute, Pusan National University Hospital, 179, Gudeok-ro, Seo-gu, Busan, 49241, South Korea. isbyon@naver.com.

Funding

Pusan National University Hospital, Biomedical Research Institute 202400550001

6 · The paper itself

Abstract

This study aimed to evaluate macular blood flow changes in a Korean population using quantitative optical coherence tomography angiography (OCTA). Healthy Korean participants were imaged with swept-source OCTA, and all eyes were scanned twice using a 6 × 6 mm protocol centered on the fovea. En face images of the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) were obtained with a multilayer segmentation algorithm. Quantitative parameters included CC flow deficits (CCFDs) and vessel density (VD) in the SCP and DCP, with the main outcome being age-related changes in these parameters. Of 436 participants, 351 were included and categorized by age: 20s (n = 57), 30s (n = 37), 40s (n = 42), 50s (n = 44), 60s (n = 76), 70s (n = 76), and 80s (n = 19). The 20s group had higher SCP VDs (37.3%) than the 50s (36.7%), 60s (36.6%), 70s (36.2%), and 80s (35.6%) (p < 0.05). DCP VD was lower in the 20s (26.2%) than in the 60s (27.2%), 70s (27.7%), and 80s (28.5%) (p < 0.05). CCFDs were lower in the 20s (17.7%) than in all older groups (p < 0.05). In healthy Koreans, macular blood flow showed significant age-related changes, with SCP decrease (from the 50s), DCP increase (from the 60s), and CC decline (from the 30s).

Indexed as

AgingChoroidRegional Blood FlowRetinal VesselsTomography, Optical CoherenceAdultAgedBlood Flow VelocityCapillariesFemaleHumansMaleMiddle AgedRepublic of KoreaYoung AdultBlood flowChoriocapillaris flow deficitsDeep capillary plexusOptical coherence tomography angiographySuperficial capillary plexus

Identifiers

PMID41554944

DOI10.1038/s41598-026-36184-z

PMCPMC12894867

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.