Evidence map›Paper›PMID 41554938›Full record

ArticleNature biomedical engineering2026

Symbiotic transcatheter pacemaker for lifelong energy regeneration and therapeutic function in porcine disease model.

Han Ouyang, Dongjie Jiang, Yiran Hu, Sijing Cheng, Zhengmin Zhang, Bojing Shi, Engui Wang, Jiangtao Xue, Yizhu Shan, Lingling Xu and 14 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Han Ouyang *School of Nanoscience and Engineering, University of Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-5469-8235
Dongjie Jiang *School of Nanoscience and Engineering, University of Chinese Academy of Sciences, Beijing, China.
Yiran Hu *Department of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID http://orcid.org/0000-0002-6588-9037
Sijing Cheng *Department of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID http://orcid.org/0000-0003-0837-0826
Zhengmin Zhang *Hangzhou Dianzi University, Hangzhou, China.ORCID http://orcid.org/0000-0003-4675-4994
Bojing ShiKey Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.ORCID http://orcid.org/0000-0003-0802-8326
Engui WangSchool of Nanoscience and Engineering, University of Chinese Academy of Sciences, Beijing, China.
Jiangtao XueBeijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Yizhu ShanBeijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, China.
Lingling XuSchool of Nanoscience and Engineering, University of Chinese Academy of Sciences, Beijing, China.
Yang ZouBeijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Sixian WengDepartment of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID http://orcid.org/0000-0002-2466-9046
Hui LiDepartment of Ultrasound, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Hongxia NiuDepartment of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Min GuDepartment of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Lin LuoSchool of Nanoscience and Engineering, University of Chinese Academy of Sciences, Beijing, China.
Shengyu ChaoBeijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, China.
Puchuan TanBeijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, China.
Yan YaoDepartment of Cardiology, Being Anzhen Hospital, Capital Medical University, Beijing, China.ORCID http://orcid.org/0000-0003-4930-5633
Ningning WangHangzhou Dianzi University, Hangzhou, China.ORCID http://orcid.org/0000-0002-3638-3408
Yubo FanKey Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.ORCID http://orcid.org/0000-0002-3480-4395
Zhong Lin WangSchool of Nanoscience and Engineering, University of Chinese Academy of Sciences, Beijing, China.
Wei HuaDepartment of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. drhuawei@fuwai.com.ORCID http://orcid.org/0000-0001-6921-9375
Zhou LiBeijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China. li_zhou@tsinghua.edu.cn.ORCID http://orcid.org/0000-0002-9952-7296

Funding

National Natural Science Foundation of China (National Science Foundation of China) 52373256National Natural Science Foundation of China (National Science Foundation of China) 82100325National Natural Science Foundation of China (National Science Foundation of China) T2125003Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) JQ20038Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) L212010
6 · The paper itself

Abstract

Lifelong pacing is one of the ultimate goals of cardiac pacemakers. However, meeting the critical energy condition for lifelong service is a tremendous challenge. Here we report a symbiotic transcatheter pacemaker that regenerates electric energy from heart motion via electromagnetic induction and surpasses the critical energy condition for lifelong service. The pacemaker can be closely integrated with the body owing to favourable biocompatibility and hemocompatibility, and its small size enables interventional delivery. To minimize energy loss and eliminate mechanical collision and friction, we propose a straightforward magnetic levitation energy cache structure. The energy regeneration module has a near-zero boot threshold, high kinetic energy conversion efficiency and intracardiac root mean square output power. We show the energy regeneration and therapeutic function of the symbiotic transcatheter pacemaker over a month-long autonomous operation in a porcine model of brady-arrhythmia. These advances may provide a potential path to extend the service life of pacemakers to the level of the natural heart.

Identifiers

PMID41554938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.