ArticleCommunications chemistry2026
Metal surface-triggered DNAzyme catalysis for efficient DNA cleavage.
Article in Communications chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
DNAzymes conventionally require dissolved metal ions for catalytic functions. Herein, we report that metal surfaces directly activate a self-cleaving DNAzyme (PL) at solid-liquid interfaces. PL exhibits activities on copper, vanadium and tantalum surfaces, within a minimal reaction system comprising only the metal surface, PL and double-distilled water. This interfacial activation is highly material-specific, showing complete absence of activity on plastics, glass or wood etc. Mechanistic studies reveal that dissolved oxygen could react with metal surfaces to generate superoxide anions, which serve as triggers for DNA-cleavage. The reaction shows modulatable characteristics, with inhibition by ethylenediaminetetraacetic acid, catalase, nitroblue tetrazolium and cytochrome c, versus enhancement by vitamin C, glutathione and catechol. Furthermore, metal surface-mediated activation was also observed in F-8, Ag10c and I-R3 DNAzymes, indicating that this phenomenon is not an isolated occurrence. This work establishes macroscopic metals as DNAzyme's cofactors, extending DNAzyme catalysis beyond conventional homogeneous systems to heterogeneous interfacial environments.
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