Trial reportPediatric research2026
Growth at 2 years in children born preterm: donor milk versus preterm formula.
Jane E Brumbaugh, Scott A McDonald, Daniel T Robinson, Samuel J Gentle, Ariel A Salas, Sara B DeMauro, Kera M McNelis, Brenda B Poindexter, Robert D Roghair, Tarah T Colaizy and 1 more
Abstract readRandomized Controlled TrialMulticenter StudyComparative Study
In one paragraphTrial report in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Scott A McDonaldSocial, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, NC, USA.
Daniel T RobinsonNorthwestern University Feinberg School of Medicine, Chicago, IL, USA.
Samuel J GentleYale University School of Medicine, New Haven, CT, USA.
Ariel A SalasUniversity of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Sara B DeMauroUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Kera M McNelisEmory School of Medicine, Atlanta, GA, USA.
Brenda B PoindexterEmory School of Medicine, Atlanta, GA, USA.
Robert D RoghairUniversity of Iowa Carver College of Medicine, Iowa City, IA, USA.
Tarah T ColaizyUniversity of Iowa Carver College of Medicine, Iowa City, IA, USA.
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Funding
Neonatal Research Network Data Coordinating Center (DCC)U10HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 2008 to 2017
$62.3MDuke CTSA (Composite)UL1TR001117 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, LI, JENNIFER S · 2013 to 2017
$41.3MAtlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8MData Ctr for the Cooperative Neonatal Research NetworkU01HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 1998 to 2007
$21.8MThe University of Rochester's Clinical and Translational Science InstituteUL1TR000042 · NCATS · UNIVERSITY OF ROCHESTER · PI BENNETT, NANCY M, KIEBURTZ, KARL D. · 2012 to 2015
$14.4MUniversity of Iowa Clinical and Translational Science ProgramUL1TR000442 · NCATS · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2012 to 2013
$10.0MUniversity of New Mexico Clinical and Translational Science CenterUL1TR000041 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LARSON, RICHARD S · 2012 to 2014
$9.8MNICHD Cooperative Multicenter Neonatal Research NetworkU10HD021373 · NICHD · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI KENNEDY, KATHLEEN A · 1991 to 2015
$6.1MIndiana Clinical and Translational Science Institute (UL1)UL1TR000006 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI SHEKHAR, ANANTHA · 2012 to 2013
$5.6MNICHD Neonatal Research Network -- Cincinnati Clinical CenterUG1HD027853 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI STEPHANIE L MERHAR · 2016 to 2026
$3.7MClinical Center for NICHD/Neonatal Research NetworkUG1HD068244 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI Sara Bonamo DeMauro, Eric C Eichenwald · 2016 to 2026
$3.6MNICHD COPPERATIVE MULTICENTER NEONATAL RESEARCH NETWORKUG1HD040689 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI Myra Helen Wyckoff · 2016 to 2026
$3.5MNCATS NIH HHS UL1 TR000006NCATS NIH HHS UL1 TR000041NCATS NIH HHS UL1 TR000042NCATS NIH HHS UL1 TR000442NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR001117NICHD NIH HHS U01 HD036790NICHD NIH HHS U10 HD021373NICHD NIH HHS U10 HD036790NICHD NIH HHS UG1 HD021364NICHD NIH HHS UG1 HD021385NICHD NIH HHS UG1 HD027851NICHD NIH HHS UG1 HD027853NICHD NIH HHS UG1 HD027856NICHD NIH HHS UG1 HD027904NICHD NIH HHS UG1 HD034216NICHD NIH HHS UG1 HD040492NICHD NIH HHS UG1 HD040689NICHD NIH HHS UG1 HD053089NICHD NIH HHS UG1 HD053109NICHD NIH HHS UG1 HD068244NICHD NIH HHS UG1 HD068263NICHD NIH HHS UG1 HD068270NICHD NIH HHS UG1 HD068278NICHD NIH HHS UG1 HD068284NICHD NIH HHS UG1 HD087226NICHD NIH HHS UG1 HD087229
6 · The paper itselfAbstract
backgroundThe NICHD Neonatal Research Network MILK Trial randomized infants born preterm to receive donor milk or preterm formula. We hypothesized that there would be no growth differences at follow-up by study diet.
methodsWe conducted a secondary analysis of the double-blind trial of infants <29 weeks' gestation or <1000 g at birth at 15 US centers (September 2012-March 2019). Infants were randomized to receive donor milk or preterm formula. The primary outcome was body mass index (BMI) Z-score at 22-26 months corrected age.
resultsAmong 483 trial participants, 376 were seen at follow-up (181 donor milk, 195 formula). At 22-26 month follow-up, anthropometrics were similar for the two groups, including BMI Z-score (donor milk 0.21 ± 1.13, formula 0.23 ± 1.28, p = 0.67). There was a greater increase in weight Z-score between discharge and follow-up for children randomized to donor milk (donor milk 1.04 ± 1.28, formula 0.73 ± 1.30, p = 0.004).
conclusionsWhile BMI Z-scores were similar at 22-26 months corrected age, patterns of growth between discharge and follow-up differed by study diet. Children fed donor milk in early infancy showed a greater increase in weight Z-score between discharge and follow-up than children fed preterm formula in early infancy. IMPACT: At 2 years, the anthropometrics were similar for children randomized to donor milk or preterm formula in early infancy. Patterns of growth between discharge and follow-up differed by early infancy diet. There was a greater weight Z-score increase between discharge and follow-up for children randomized to donor milk than formula. Donor milk appears to be non-inferior to preterm formula with respect to growth at 2 years for children born extremely preterm. Policies and practices that facilitate parental milk provision and donor milk availability are needed for infants born extremely preterm.
Indexed as
Child DevelopmentInfant FormulaInfant, PrematureMilk, HumanAnimalsBody Mass IndexChild, PreschoolDouble-Blind MethodFemaleFollow-Up StudiesHumansInfantInfant, NewbornInfant Nutritional Physiological PhenomenaMale
Identifiers
PMID41554863
PMCPMC13383060
What OpenQuestion holds
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