ArticleNature communications2026
In-memory analog computing for non-negative matrix factorization.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Non-negative matrix factorization (NMF) is a powerful technique for extracting latent structures from high-dimensional data, with applications spanning recommender systems, bioinformatics, and image processing. However, conventional digital hardware struggles to efficiently handle large-scale NMF due to computational complexity and memory bottlenecks. In this work, we propose an in-memory analog NMF solver based on a reconfigurable compact generalized inverse circuit, optimized using the conductance compensation principle. This circuit significantly reduces power consumption by minimizing the number of operational amplifiers while supporting various non-negative regression constraints. By integrating the alternating non-negative least squares algorithm, we achieve efficient and accurate factorization with a limited number of iterations. Experimental validation demonstrates the effectiveness of our analog NMF solver in real-world tasks, including image compression and collaborative filtering-based recommender systems, achieving high accuracy with orders-of-magnitude improvements in speed and energy efficiency over FPGA- and GPU-based digital solvers. These results highlight the potential of analog matrix computing for enabling real-time, large-scale NMF applications.
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