ArticleLight, science & applications2026
Plan meta-objective for sub-micron quantitative phase imaging.
Article in Light, science & applications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
11 authors.
Funding
Abstract
Quantitative phase imaging (QPI) provides valuable objective insights for investigating transparent samples, yet miniaturizing QPI systems without compromising performance remains a critical challenge for applications requiring compactness and portability. Here, by introducing partially coherent illumination modulation, together with a plan meta-objective (PMO) design, we present a compact QPI system with sub-micron resolution. The PMO is a monolithically integrated doublet metalens with its dispersion enabling focal shifts at two wavelengths, obviating the need for mechanical translations during image acquisition for phase retrieval. The PMO is also optimized to correct for monochromatic aberrations, delivering an object-side field of view equivalent to ~90% of the lens aperture with minimal distortion and aberrations. The spatial coherence of the illumination is controlled to enhance imaging resolution. By co-designing illumination and imaging systems, we demonstrate QPI achieving a half-pitch lateral resolution of 488 nm with a phase accuracy of 0.06λ. Our approach enables high-quality QPI analysis of diverse phase objects, including unstained biospecimens, laying the foundation for the development of compact, stable, and practical QPI platforms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.