Evidence map›Paper›PMID 41554692›Full record

ArticleBone research2026

Neutrophil-initiated nociceptive ingrowth orchestrates inflammation resolution to potentiate bone regeneration.

Xuanyu Qi, Guangzheng Yang, Zeqian Xu, Mingliang Zhou, Tejing Liu, Jiahui Du, Sihan Lin, Xinquan Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xuanyu Qi *Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Guangzheng Yang *Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-6390-2939
Zeqian Xu *Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Mingliang ZhouDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tejing LiuDepartment of Oral Pathology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.
Jiahui DuDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. jiahuidu2010@126.com.ORCID 0000-0003-3238-0469
Sihan LinDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. linsihan0729@126.com.
Xinquan JiangDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. xinquanjiang@aliyun.com.ORCID 0000-0002-1490-281X

Funding

China Postdoctoral Science Foundation 2023M732283National Natural Science Foundation of China (National Science Foundation of China) 82100966National Natural Science Foundation of China (National Science Foundation of China) 82130027National Natural Science Foundation of China (National Science Foundation of China) 82301020
6 · The paper itself

Abstract

Nociceptive pain is a cardinal feature of traumatic and inflammatory bone diseases. However, whether and how nociceptors actively regulate the immune response during bone regeneration remains unclear. Here, we found that neutrophil-triggered nociceptive ingrowth functioned as negative feedback regulation to inflammation during bone healing. A unique Il4ra

Indexed as

Bone RegenerationInflammationNeutrophilsNociceptorsAnimalsAutophagyCalcitonin Gene-Related PeptideHumansLipoxinsMaleMiceMice, Inbred C57BLOsteoblastsTRPV Cation ChannelsCalcitonin Gene-Related Peptidelipoxin A4LipoxinsTRPV Cation Channels

Identifiers

PMID41554692
PMCPMC12816638

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.