Evidence map›Paper›PMID 41554630›Full record

ArticleGut2026

Associations between demographic, clinical and dietary factors and flares in inflammatory bowel disease: the PRognostic effect of Environmental factors in Crohn's and Colitis (PREdiCCt) prospective cohort study.

Nathan Constantine-Cooke, Beatriz Gros, Nikolas Plevris, Linda J Williams, Gareth-Rhys Jones, Janet Kyle, Nicholas A Kennedy, Victor Velasco-Pardo, Alexander Rudge, Debbie Alexander and 23 more

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03282903 (The PRognostic Effect of Environmental Factors in Crohn's and Colitis), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03282903 completednot on this map

The PRognostic Effect of Environmental Factors in Crohn's and Colitis

TypeobservationalSponsorUniversity of EdinburghRan2016 to 2022Enrolled2,629ConditionsInflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Plant and Animal Protein Sources in Inflammatory Bowel Disease: Current Evidence and Clinical Implications.JGH open : an open access journal of gastroenterology and hepatology · 2026
    Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Nathan Constantine-CookeInstitute of Genetics and Cancer, University of Edinburgh Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0002-4437-8713
Beatriz GrosGastroenterology Department, Reina Sofía University Hospital, IMIBIC, CIBERehd, Córdoba, Spain.
Nikolas PlevrisEdinburgh IBD Unit, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0002-3229-8759
Linda J WilliamsUsher Institute, The University of Edinburgh Usher Institute of Population Health Sciences and Informatics, Edinburgh, UK.
Gareth-Rhys JonesSchool for Infection and Immunity, University of Glasgow, Glasgow, UK.
Janet KyleInstitute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
Nicholas A KennedyGastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.
Victor Velasco-PardoInstitute of Genetics and Cancer, University of Edinburgh Western General Hospital, Edinburgh, UK.
Alexander RudgeInstitute of Genetics and Cancer, University of Edinburgh Western General Hospital, Edinburgh, UK.
Debbie AlexanderInstitute of Genetics and Cancer, University of Edinburgh Western General Hospital, Edinburgh, UK.
Carl A AndersonWellcome Trust Genome Campus, Wellcome Trust Sanger Institute, Cambridge, UK.
Maiara Brusco de FreitasClinical Medicine, Aalborg Universitet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1737-8918
Lisa M DerrUsher Institute, The University of Edinburgh Usher Institute of Population Health Sciences and Informatics, Edinburgh, UK.
Lauranne Aap DerikxDepartment of Gastroenterology, Erasmus MC, Rotterdam, The Netherlands.
Sian GilchristDepartment of Gastroenterology, NHS Fife, Kirkcaldy, UK.
Paul HendersonPaediatric Gastroenterology and Nutrition, Royal Hospital for Children and Young People, Edinburgh, UK.ORCID http://orcid.org/0000-0003-3634-6428
Graham W HorganBiomathematics and Statistics Scotland, Edinburgh, UK.
Peter IrvingSt Thomas' Hospital, London, UK.
Christopher A LambTranslational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0002-7271-4956
Luke Jostins-DeanKennedy Institute of Rheumatology, Oxford University, Oxford, UK.
James O LindsayBarts and The London School of Medicine, Queen Mary University of London, London, UK.
Jonathan MacDonaldNHS Glasgow and Greater Clyde, Glasgow, UK.
Craig MowatUniversity of Dundee, Dundee, UK.
Charles MurrayGastroenterology, Royal Free Hospital, London, UK.
Miles ParkesDepartment of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Spyros I SiakavellasGastroenterology Department, University of Edinburgh Western General Hospital, Edinburgh, UK.
Catalina A VallejosInstitute of Genetics and Cancer, University of Edinburgh Western General Hospital, Edinburgh, UK.
Daniel R GayaNHS Glasgow and Greater Clyde, Glasgow, UK.
Jonathan M RhodesUniversity of Liverpool Department of Molecular and Clinical Cancer Medicine, Liverpool, UK.ORCID http://orcid.org/0000-0002-1302-260X
Alexandra M JohnstoneUniversity of Aberdeen, The Rowett Institute, Aberdeen, UK.
Christopher J WeirThe University of Edinburgh Usher Institute, Edinburgh, UK.
Charlie W LeesInstitute of Genetics and Cancer, University of Edinburgh Western General Hospital, Edinburgh, UK charlie.lees@ed.ac.uk.ORCID http://orcid.org/0000-0002-0732-8215
PREdiCCt study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIBD is characterised by recurrent flares, but evidence on whether modifiable dietary factors influence flare risk is limited.

objectiveThe PREdiCCt study was designed to examine demographic, clinical and dietary factors associated with disease flare among patients with IBD in self-reported remission.

designMulticentre, prospective cohort study conducted across 47 UK centres. Patients with Crohn's disease (CD), ulcerative colitis (UC) or IBD unclassified (IBDU) in self-reported remission were prospectively followed up. The baseline diet was assessed using a validated food frequency questionnaire. The primary outcome was time to patient-reported flare (captured by monthly IBD-Control) and objective flare (clinical flare plus C-reactive protein >5 mg/L and/or faecal calprotectin (FC) >250 µg/g with treatment escalation). Associations were evaluated using Cox frailty models adjusted for demographic, clinical and biochemical variables, including baseline FC.

resultsBetween November 2016 and March 2020, 2629 participants (1370 CD; 1259 UC/IBDU) were enrolled and followed up for a median of 4.1 years (IQR 3.0-5.0). Baseline FC was strongly associated with patient-reported flares (FC ≥250 µg/g: adjusted HR (aHR) 2.22; FC 50-250 µg/g: aHR 1.52 (reference <50 µg/g)) and objective flares (FC ≥250 µg/g: aHR 3.25; FC 50-250 µg/g: aHR 1.98). In UC, higher total meat intake was associated with increased risk of objective flares (highest versus lowest quartile: aHR 1.95, 95% CI 1.07 to 3.56). No consistent associations were observed for ultraprocessed foods, fibre or polyunsaturated fatty acids and flare.

conclusionHigher habitual meat intake was associated with increased risk of objective flare in UC, suggesting diet may contribute to flare susceptibility in specific patient groups. TRIAL REGISTRATION NUMBER: NCT03282903.

Indexed as

Colitis, UlcerativeCrohn DiseaseDietSymptom Flare UpAdultCohort StudiesC-Reactive ProteinFecesFemaleHumansInflammatory Bowel DiseasesLeukocyte L1 Antigen ComplexMaleMeatMiddle AgedPrognosisC-Reactive ProteinLeukocyte L1 Antigen ComplexCROHN'S DISEASEDIETINFLAMMATORY BOWEL DISEASEULCERATIVE COLITIS

Identifiers

PMID41554630
PMCPMC13479245

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.