Evidence map›Paper›PMID 41554321›Full record

ReviewGeneral and comparative endocrinology2026

Toxins in disguise: Neuropeptide mimicry across animal venoms.

Thomas Lund Koch, Helena Safavi-Hemami

Abstract readReview
In one paragraph

Review in General and comparative endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Thomas Lund KochDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA; School of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA; Department of Biomedical Sciences, University of Copenhagen, Copenhagen N DK-2200, Denmark. Electronic address: t.l.koch@ibv.uio.no.
Helena Safavi-HemamiDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA; School of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: helena.safavi@biochem.utah.edu.

Funding

Discovery and design of novel insulin evologs from venomous marine cone snailsR01DK139317 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Helena Safavi-Hemami · 2024 to 2026
$1.1M
NIDDK NIH HHS R01 DK139317
6 · The paper itself

Abstract

Neuropeptides and peptide hormones form a highly diverse class of signaling molecules found across the animal kingdom that regulate key physiological processes, including growth, metabolism, reproduction, and behavior. Many venomous animals have evolved "doppelgänger toxins" that mimic these endogenous peptides, allowing them to manipulate the physiology of their prey or predators. These toxins typically act on the same receptors as the peptides they mimic, most commonly G protein-coupled receptors, but also receptor tyrosine kinases, membrane-bound guanylyl cyclases, and ion channels. Although doppelgänger peptides have been described in other ecological contexts, this review focuses on venom-derived mimics, summarizing their molecular characteristics, evolutionary context, and biological functions. We catalogue examples spanning conserved bilaterian neuropeptides to lineage-specific families and discuss their translational potential in medicine and pest control.

Indexed as

NeuropeptidesVenomsAnimalsNeuropeptidesVenomsDoppelgänger peptidesDoppelgänger toxinsEvolutionHormonesNeuropeptidesVenom

Identifiers

PMID41554321
PMCPMC13311285

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.