Evidence map›Paper›PMID 41554124›Full record

Trial reportAnnals of internal medicine2026

Effect of Social Vulnerability on Efficacy of Bariatric Surgery Versus Medical and Lifestyle Intervention for Type 2 Diabetes: Analysis of the ARMMS-T2D Consortium of Randomized Trials.

Mary Elizabeth Patti, Bo Hu, Sarah Kirschling, Hanna J Wang, Kathleen Foster, Yael Sarig, Donald C Simonson, Danielle Wolfs, David Arterburn, Matthew J O'Brien and 11 more

Registry-linked trialAbstract readMulticenter StudyComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02328599 (A Prospective Consortium Evaluating the Long-term Follow-up of Patients With Type 2 Diabetes Enrolled In a Randomized Controlled Trial Comparing Bariatric Surgery Versus Medical Management), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02328599 completednot on this map

A Prospective Consortium Evaluating the Long-term Follow-up of Patients With Type 2 Diabetes Enrolled In a Randomized Controlled Trial Comparing Bariatric Surgery Versus Medical Management

TypeobservationalSponsorAli AminianRan2018 to 2024Enrolled262ConditionsType 2 Diabetes Mellitus, ObesityArmsBariatric surgery involving Roux-en-Y gastric bypass, Bariatric surgery involving Laparoscopic adjustable gastric banding, Bariatric surgery involving Laparoscopic sleeve gastrectomy
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Mary Elizabeth PattiResearch and Clinic Division, Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts (M.E.P., H.J.W., K.F., Y.S., D.W., L.L., S.O.).ORCID 0000-0002-8163-3429
Bo HuDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio (B.H., S.K.).
Sarah KirschlingDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio (B.H., S.K.).ORCID 0000-0003-1054-4186
Hanna J WangResearch and Clinic Division, Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts (M.E.P., H.J.W., K.F., Y.S., D.W., L.L., S.O.).
Kathleen FosterResearch and Clinic Division, Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts (M.E.P., H.J.W., K.F., Y.S., D.W., L.L., S.O.).
Yael SarigResearch and Clinic Division, Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts (M.E.P., H.J.W., K.F., Y.S., D.W., L.L., S.O.).
Donald C SimonsonBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (D.C.S., A.H.V.).ORCID 0000-0002-4670-6290
Danielle WolfsResearch and Clinic Division, Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts (M.E.P., H.J.W., K.F., Y.S., D.W., L.L., S.O.).
David ArterburnKaiser Permanente Washington Health Research Institute, Seattle, Washington (D.A.).
Matthew J O'BrienDivision of General Internal Medicine and Epidemiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois (M.J.O.).
Ashley H VernonBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (D.C.S., A.H.V.).
John M JakicicDepartment of Internal Medicine, Division of Physical Activity and Weight Management, University of Kansas Medical Center, Kansas City, Kansas (J.M.J.).
Lori LaffelResearch and Clinic Division, Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts (M.E.P., H.J.W., K.F., Y.S., D.W., L.L., S.O.).
Sando OjukwuResearch and Clinic Division, Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts (M.E.P., H.J.W., K.F., Y.S., D.W., L.L., S.O.).
Sangeeta R KashyapWeill Cornell Medicine-New York Presbyterian, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, New York, New York (S.R.K.).ORCID 0000-0002-7489-6650
Ali AminianBariatric and Metabolic Institute, Department of General Surgery, Cleveland Clinic, Cleveland, Ohio (A.A.).ORCID 0000-0001-5756-9917
Philip R SchauerMetamor Institute, Pennington Biomedical Research Center, Baton Rouge, Louisiana (P.R.S., J.P.K.).
David E CummingsDepartment of Medicine, University of Washington, and VA Puget Sound Health Care System, Seattle, Washington (D.E.C.).
William F GourashDepartment of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania (W.F.G., A.C.).
Anita CourcoulasDepartment of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania (W.F.G., A.C.).
John P KirwanMetamor Institute, Pennington Biomedical Research Center, Baton Rouge, Louisiana (P.R.S., J.P.K.).ORCID 0000-0001-7321-9917

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
Research Design, Data, and Analytics CoreP30DK092949 · NIDDK · UNIVERSITY OF CHICAGO · PI MILDA Renne SAUNDERS · 2011 to 2026
$10.0M
Alliance of Randomized Trials of Medicine vs Metabolic Surgery in Type 2 Diabetes - (ARMMS-T2D)U01DK114156 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI AMINIAN, ALI, KIRWAN, JOHN P. · 2017 to 2022
$8.9M
NIDDK NIH HHS P30 DK036836NIDDK NIH HHS P30 DK092949NIDDK NIH HHS U01 DK114156NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

backgroundSocial determinants of health (SDOH) can affect metabolic health.

objectiveTo determine the effect of social vulnerability on the comparative effectiveness of metabolic bariatric surgery or medical and lifestyle intervention on glycemia and weight outcomes in people with type 2 diabetes (T2D).

designAnalysis of the effect modification of baseline Area Deprivation Index (ADI; a metric of social vulnerability) on longitudinal outcomes between randomized treatment groups using linear mixed-effects models. (ClinicalTrials.gov: NCT02328599).

setting4 U.S. academic centers.

participants258 participants with T2D enrolled in 4 randomized controlled trials of surgical versus medical management and a longitudinal observational follow-up study. MEASUREMENTS: ADI linked to ZIP code data at randomization; weight loss and hemoglobin A

resultsBaseline characteristics were well balanced between the surgical and medical therapy groups after adjustment for study site and stratification by high versus low ADI. Surgery was more effective than medical therapy in reducing HbA LIMITATIONS: Small sample size; parent trials were not designed to address effect modification by ADI.

conclusionSurgery was superior to medical therapy for people with T2D regardless of social deprivation. This study did not detect statistically significant differences in the comparative advantage of surgery over medical therapy by ADI. PRIMARY FUNDING SOURCE: National Institutes of Health.

Indexed as

Bariatric SurgeryDiabetes Mellitus, Type 2Hypoglycemic AgentsLife StyleSocial Determinants of HealthAdultBlood GlucoseFemaleGlycated HemoglobinHumansMaleMiddle AgedWeight LossBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanHypoglycemic Agents

Identifiers

PMID41554124
PMCPMC12958453

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.