ArticleAnalytical chemistry2026
Lab-on-a-Chip Metabolic Analysis Using Benchtop NMR Technology.
Article in Analytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Hyperpolarised magnetic resonance spectroscopy with lab-on-a-chip disease models.Disease models & mechanisms · 2026Review
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organ-on-chip (OoC) systems are advancing rapidly as physiologically relevant in vitro models. However, real-time, noninvasive metabolic monitoring tools remain lacking. While NMR offers a powerful solution, current setups are not compatible with the planar format of microfluidic chips. Here we introduce the first benchtop NMR spectrometer for real-time metabolic monitoring of cell cultures on microfluidic platforms, utilizing hyperpolarization via dissolution dynamic nuclear polarization. This work details modifications made to a commercial benchtop NMR spectrometer, including the design and fabrication of a microfluidic platform that enables precise injection of hyperpolarized substrates and continuous renewal of cell culture media. The platform integrates a radiofrequency coil for signal transmission and reception and incorporates a custom-built sample carrier. Preliminary NMR data acquired with this system demonstrate its feasibility for dynamic metabolic studies.
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Registered trials
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