Evidence map›Paper›PMID 41553822›Full record

ArticleCell reports2026

Activation of nuclear Ca

Yu-Ping Lin, Abdull J Massri, Yi-Ting Huang, Sara A Grimm, Anant B Parekh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yu-Ping LinLaboratory of Molecular and Cellular Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Durham, NC 27709, USA.
Abdull J MassriIntegrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Durham, NC 27709, USA.
Yi-Ting HuangLaboratory of Molecular and Cellular Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Durham, NC 27709, USA.
Sara A GrimmIntegrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Durham, NC 27709, USA.
Anant B ParekhLaboratory of Molecular and Cellular Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Durham, NC 27709, USA. Electronic address: anant.parekh@nih.gov.

Funding

Calcium Signaling in Health and DiseaseZIAES103353 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI PAREKH, ANANT · 2020 to 2025
$15.5M
Intramural NIH HHS ZIA ES103353
6 · The paper itself

Abstract

Oscillations in the levels of second messengers are observed throughout the phylogenetic tree, with signaling information encoded in the frequency of the spikes. Different biological targets respond to different frequencies of oscillation, leading to the concept of frequency counting. The most widely observed and best understood oscillatory second messenger is cytosolic Ca

Indexed as

CalciumCalcium Release Activated Calcium ChannelsCell NucleusGene Expression RegulationAnimalsCalcium SignalingCytosolHumansNFATC Transcription FactorsNF-kappa BCalciumCalcium Release Activated Calcium ChannelsNFATC Transcription FactorsNF-kappa BCalcium channelcalcium oscillationsCP: cell biologygene expressionnanodomainNFATstore operated

Identifiers

PMID41553822
PMCPMC13001029

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.