Evidence map›Paper›PMID 41553699›Full record

ArticleGeroScience2026

Age and sex shape plasma lipid associations to skeletal muscle mitochondrial respiration and H

Nicholas A Carlini, Bradley A Ruple, Helya Rostamkhani, Huihui Shi, J Alan Maschek, Brady E Hanson, Namakkal Soorappan Rajasekaran, Russell S Richardson, Micah J Drummond, Ryan M Broxterman and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nicholas A CarliniDepartment of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah, USA.
Bradley A RupleDepartment of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah, USA.
Helya RostamkhaniDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.
Huihui ShiGeriatric Research, Education, and Clinical Center, George E. Wahlen Veterans Affairs Medical Center, Salt Lake City, UT, USA.
J Alan MaschekMetabolomics Core Research Facility, University of Utah, Salt Lake City, USA.
Brady E HansonDepartment of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah, USA.
Namakkal Soorappan RajasekaranCardiac Aging and Redox Signaling Laboratory, Molecular and Cellular Pathology, Department of Pathology/Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham Alabama, USA.
Russell S RichardsonDepartment of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah, USA.
Micah J DrummondDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.
Ryan M BroxtermanDepartment of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah, USA.
Joel D TrinityDepartment of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah, USA. joel.trinity@utah.edu.

Funding

Reductive Stress Induces Proteotoxic Cardiac DiseaseR01HL118067 · NHLBI · UNIVERSITY OF UTAH · PI NAMAKKAL SOORAPPAN, RAJASEKARAN · 2013 to 2021
$4.5M
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction during DisuseR01HL142603 · NHLBI · UNIVERSITY OF UTAH · PI TRINITY, JOEL DOUGLAS · 2019 to 2023
$2.9M
Agilent 6550 QTOF system for U of UtahS10OD016232 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2013 to 2013
$578k
Q-ToF Mass Spectrometer for the University of Utah MS and Proteomics CoreS10OD018210 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2015 to 2015
$530k
Agilent 7200 GC/Q-TOF for the University of UtahS10OD021505 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2016 to 2016
$401k
Antioxidant Defense Mechanisms: Nrf2/Keap1 Signaling in Aging HeartR03AG042860 · NIA · UNIVERSITY OF UTAH · PI NAMAKKAL SOORAPPAN, RAJASEKARAN · 2012 to 2013
$145k
CSRD VA I01 CX001999CSRD VA IK2 CX002114NHLBI NIH HHS R01 HL118067NHLBI NIH HHS R01 HL142603NIA NIH HHS R03 AG042860NIH HHS HL142603NIH HHS S10 OD016232NIH HHS S10 OD018210NIH HHS S10 OD021505RRD VA I01 RX003810U.S. Department of Veterans Affairs I01RX003810U.S. Department of Veterans Affairs IK2CX002114
6 · The paper itself

Abstract

Aging changes the lipidome and mitochondrial function in a sex-dependent manner, yet their associations remain poorly understood. Twenty-four younger (7M/17F) and forty-three older (21M/22F) adults underwent blood draws and skeletal muscle biopsies for this cross-sectional investigation. Plasma lipidomic profiling was performed via liquid chromatography-tandem mass spectrometry, while peak mitochondrial O

Indexed as

AgingHydrogen PeroxideLipidsMitochondria, MuscleMuscle, SkeletalAdultAgedAge FactorsCross-Sectional StudiesFemaleHumansLipidomicsMaleMiddle AgedOxygen ConsumptionSex FactorsHydrogen PeroxideLipidsAgingBiological sexLipidsMitochondriaSkeletal muscle

Identifiers

PMID41553699
PMCPMC13638858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.