ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2026
Triple composite based on metal-organic framework: differences in production of reactive oxygen species in biological and non-biological media.
Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
A significant challenge in nanoscience is the unpredictable translation of activity of reactive oxygen species (ROS) from chemical to biological environments; this is the result of the complexity of biological regulatory mechanisms, antioxidant defenses, and interactions with cellular components (enzymes, membranes, etc.). The paper studies bioeffects of magnetically-controlled ROS-inducing compounds: triple composite Fe₃O₄-HA-MOF and its components (Fe₃O₄-MOF, HA, and MOF), where Fe₃O₄, HA, and MOF represent magnetite, humic acids, and metal-organic framework MIL-88B. ROS levels were evaluated in different media: non-biological (distilled water and 3%NaCl solution) and biological (bacterial cells Photobacterium phosphoreum and isolated bacterial enzymes). Luminol chemiluminescence method was used to assess ROS content. Variations of ROS content in non-biological media were revealed. Based on spectrophotometric and electrochemical analyses, the variations were explained by MOF degradation, iron ion release, and HA desorption. In biological systems, all compounds exhibited a unified effect: enzymes completely neutralized ROS deviations; bacteria stabilized ROS contents at ~ 50% excess level, likely due to their regulatory mechanisms. Similar living-cell-like effect was found for HA-containing compounds (HA and Fe₃O₄-HA-MOF) in non-biological media. The bacterial bioluminescence was used as a traditional cellular bioassay: it did not detect toxicity of all compounds under the experimental conditions. Our findings suggest that bioeffects of Fe₃O₄-MOF-based composites depend on the properties of the third component-modificator (HA or other). It was concluded that it is impossible to predict ROS activity in biological media based solely on the physicochemical analyses; simple cellular bioassays (similar to bioluminescence bacterial assay) are recommended for accurate predictions.
Indexed as
Identifiers
41553694What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.