Evidence map›Paper›PMID 41553688›Full record

ArticleInternational journal of hematology2026

Hearing loss in Langerhans cell histiocytosis: close association with central nervous system consequences.

Akira Kaino, Kenichi Sakamoto, Kunihiko Moriya, Shinya Osone, Toshihiko Imamura, Kazuko Kudo, Yoko Shioda, Shinsaku Imashuku, Akira Morimoto, Japan Langerhans Cell Histiocytosis Study Group

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Article in International journal of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Akira KainoDepartment of Pediatrics, Tohoku University School of Medicine, Sendai, Japan.
Kenichi SakamotoDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan. sakamoto-k@shinshu-u.ac.jp.ORCID http://orcid.org/0000-0003-1499-538X
Kunihiko MoriyaDepartment of Pediatrics, National Defense Medical College, Tokorozawa, Japan.
Shinya OsoneDepartment of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Toshihiko ImamuraAnyoji Kids' Clinic, Ritto, Japan.
Kazuko KudoDepartment of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.
Yoko ShiodaChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Shinsaku ImashukuDepartment of Laboratory Medicine, Uji-Tokushukai Medical Center, Uji, Japan.
Akira MorimotoDivision of Pediatrics, Showa Inan General Hospital, Komagane, Japan.
Japan Langerhans Cell Histiocytosis Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHearing loss is a recognized permanent consequence (PC) of Langerhans cell histiocytosis (LCH). However, its characteristics and association with central nervous system (CNS)-related PCs remain unclear. PROCEDURE: This study retrospectively analyzed the data of 317 pediatric patients with multisystem or multifocal bone LCH enrolled in the Japan LCH Study Group -96 or -02 trial.

resultsHearing loss was identified in nine patients (2.8%), a lower incidence than previously reported. It was significantly associated with ear lesions, but not with craniofacial bone involvement at the time of diagnosis. Detailed information was available for seven patients: Three had sensorineural hearing loss, and four had mixed-type hearing loss without hearing improvement. At the last follow-up, hearing loss was unilateral in six cases and bilateral in one, with severity ranging from moderate (n = 1) to severe (n = 2) and profound (n = 4). CNS-PCs were found in five patients and were significantly associated with hearing loss (p = 0.018). One patient without ear lesions developed progressive sensorineural hearing loss due to neurodegeneration (ND).

conclusionsPatients with hearing loss should be closely monitored for CNS-PCs, and those with LCH-associated ND should be carefully monitored for the development of sensorineural hearing loss.

Indexed as

Central Nervous SystemHearing LossHearing Loss, SensorineuralHistiocytosis, Langerhans-CellAdolescentChildChild, PreschoolFemaleHumansInfantJapanMaleRetrospective StudiesCentral diabetes insipidusHearing lossLangerhans cell histiocytosisNeurodegenerationSensorineural

Identifiers

PMID41553688

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.