ReviewAdvances in experimental medicine and biology2026
Lipid Metabolism as a Target Site in Pest Control.
Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Lipid metabolism is essential to insect life as insects use lipids for their development, reproduction, flight, diapause, and a wide range of other functions. The central organ for insect lipid metabolism is the fat body, which is analogous to mammalian adipose tissue and liver, albeit less structured. Various other systems including the midgut, brain, and neural organs also contribute functionally to insect lipid metabolism. Lipid metabolism is under the control of core lipogenic [e.g. acetyl-CoA-carboxylase (ACC), fatty acid synthase (FAS), perilipin 2 (LSD2)], and lipolytic (lipases, perilipin 1) enzymes that are primarily expressed in the fat body, as well as hormones [insulin-like peptides (ILP), adipokinetic hormone (AKH)], transcription factors (SREBPs, foxO, and CREB), secondary messengers (calcium) and post-translational modifications (phosphorylation). Essential roles of the fat body, together with the fact that proper coordination of lipid metabolism is critical for insects, render lipid metabolism an attractive target site in pest control. In the current chapter, we focus on pest control tactics that target insect lipid metabolism. Various classes of traditional chemical insecticides [e.g. organophosphates, pyrethroids, neonicotinoids, and chitin synthesis inhibitors (Sects. 2.1 and 2.2)] have been shown to interfere with lipid metabolism, albeit it is not their primary site of action. However, the discovery of "lipid biosynthesis inhibitors", tetronic and tetramic acid derivatives commonly known as ketoenols (Sect. 2.3), was a milestone in applied entomology as they directly target lipid biosynthesis, particularly in sucking pests. Spirodiclofen, spiromesifen, and spirotetramat targeting ACC act against various insect and mite pests, while spiropidion and spidoxamat have been introduced to the market only recently. Efforts have concentrated on the development of chemical alternatives, such as hormone agonists and antagonists (Sect. 2.4), dsRNA-based pesticides that depend on RNA interference, which have great potential in pest control (Sect. 2.5) and other eco-friendly alternatives (Sect. 2.6).
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