Evidence map›Paper›PMID 41553623›Full record

ReviewNeurology and therapy2026

Dementia in Progressive Supranuclear Palsy: A Narrative Review.

Kathleen S Moore, Yara S Stipho, Nicki Niemann, Holly A Shill, Justine Chan, Crystal J Abrego, Danielle Eagan, Boris Decourt, Marwan N Sabbagh

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kathleen S MooreCreighton University School of Medicine-Phoenix, Phoenix, AZ, USA.
Yara S StiphoSchool of Public Health, University of Arizona, Tucson, AZ, USA.
Nicki NiemannBarrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
Holly A ShillBarrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
Justine ChanBarrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
Crystal J AbregoBarrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
Danielle EaganBarrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
Boris DecourtDepartment of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Marwan N SabbaghBarrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA. Neuropub@barrowneuro.org.ORCID http://orcid.org/0000-0001-8139-3309

Funding

Research Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI ALIREZA ATRI · 2021 to 2026
$24.9M
Alzheimer's Drug Discovery Foundation GC-2013717National Institutes of Health - Department of Bioethics R01AG059008National Institutes of Health - Department of Bioethics R01AG073212NIA NIH HHS P30 AG072980
6 · The paper itself

Abstract

Progressive supranuclear palsy (PSP) is an adult-onset neurodegenerative disorder characterized by postural instability, ocular motor dysfunction, akinesia, and cognitive impairment. The accumulation of tau protein disrupts microtubule dynamics and axonal transport, leading to neurodegeneration in subcortical structures such as the basal ganglia and brainstem. These effects result in the clinical features of motor dysfunction and cognitive impairment associated with PSP. Dementia in patients with PSP is common but may be difficult to diagnose. This narrative review describes the cognitive decline and dementia associated with PSP. The pathological hallmarks of PSP, clinical features, and diagnostic criteria are also discussed to provide additional context for the diagnosis of PSP dementia.

Indexed as

Cognitive declineDementiaMovement disorderProgressive supranuclear palsy

Identifiers

PMID41553623
PMCPMC12965954

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.