ArticlePituitary2026
Reappraisal of colorectal polyps in acromegaly: study on prevalence, recurrence and risk factors.
Article in Pituitary, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveInvestigation of colorectal polyps’ prevalence and recurrence risk factors in acromegaly.
designRetrospective study.
methods171 patients referring to “Federico II” University diagnosed with acromegaly from 2000 to 2022 who underwent at least one colonoscopy.
resultsColonoscopy was performed at diagnosis in 120 (70.2%) and after a disease duration of 10.2 ± 5.7 years in 51 patients (29.8%). Polyps were found in 37.5% and 37.2%, respectively (p = 0.975). At diagnosis, polyps were found more frequently in older (p = 0.003), diabetic (p = 0.01) patients, with higher number of systemic complications (p < 0.001). Prevalence of polyps at diagnosis was significantly higher in patients with presumed disease onset greater than 6 years (median, p = 0.04). In patients who underwent colonoscopy after the diagnosis, age at diagnosis (p = 0.005), fasting glucose (p < 0.001), HbA1c (p < 0.001), HOMAIR (p = 0.009), and number of systemic complications (p = 0.004) were significantly higher in patients with than those without polyps. Forty-nine patients (34.2%) underwent multiple evaluations with 10-years median of colonoscopy follow-up. Recurrence was present in 38.2% at last evaluation, particularly in patients with uncontrolled acromegaly (p = 0.003), glucose metabolism impairment (p = 0.031), metabolic syndrome (MS, p = 0.004). New onset of polyps at last evaluation was found in 24.2% of patients with first negative colonoscopy, particularly in men (p = 0.006), with uncontrolled acromegaly (p = 0.007), and MS (p = 0.002). Patients with uncontrolled acromegaly had a risk 9.6- and 11.5- fold higher of polyps’ recurrence and new onset, respectively. Overall, six patients (3.5%) had colon cancer.
conclusionsPolyps’ recurrence and new onset are more frequent in patients with uncontrolled acromegaly, glucose metabolism impairment, and MS. Colonoscopy follow-up should be tailored, colonoscopy should be performed at diagnosis and periodically thereafter depending on acromegaly and metabolic control.
Indexed as
Identifiers
41553573What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.