ReviewCurrent microbiology2026
Genetically Encoded Near-Infrared Fluorescent Proteins for Viral Imaging and Detection: A Mini-Review.
Review in Current microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteriophytochrome-derived near-infrared fluorescent proteins (NIR FPs) provide deep tissue penetration, low autofluorescence, and endogenous biliverdin compatibility, enabling non-invasive visualization of viral processes in living systems. Engineering advances (iRFPs, monomeric miRFPs, photoactivatable PAiRFPs) have improved brightness, stability, and genetic encodability for robust use in mammalian models. These reporters support real-time tracking of infection dynamics and host-virus interactions and power diagnostic platforms including reporter viruses, CRISPR-based assays, and nanotechnology-enhanced biosensors. Multimodal integration with photoacoustic tomography and PET further extends their translational utility. Remaining challenges include brightness/photostability limits and the need for broader translational validation, yet progress in structure-guided mutagenesis, computational/AI-assisted protein design, and hybrid imaging strategies promises to close these gaps. This mini-review synthesizes the design principles, viral imaging/detection use cases, and translational prospects of bacteriophytochrome-derived NIR FPs, highlighting their potential to advance viral surveillance, therapeutic evaluation, and precision diagnostics.
Indexed as
Identifiers
41553557What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.