Evidence map›Paper›PMID 41553451›Full record

ArticleMagma (New York, N.Y.)2026

Robust determination of deuterium abundance in water.

Robin A de Graaf, Monique A Thomas, Graeme F Mason, Raimund I Herzog, Henk M De Feyter

Abstract read
In one paragraph

Article in Magma (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Robin A de GraafDepartments of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA. robin.degraaf@yale.edu.ORCID http://orcid.org/0000-0002-6570-7010
Monique A ThomasDepartments of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
Graeme F MasonDepartments of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
Raimund I HerzogDepartments of Internal Medicine, Yale University, New Haven, CT, 06520, USA.
Henk M De FeyterDepartments of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.

Funding

Deuterium metabolic imaging (DMI) of neurological diseaseR01EB025840 · NIBIB · YALE UNIVERSITY · PI ROBIN A DE GRAAF, Henk De Feyter · 2019 to 2026
$4.2M
Regulation of Brain Glucose Metabolism in Type 1 DiabetesR01DK101984 · NIDDK · YALE UNIVERSITY · PI HERZOG, RAIMUND INGO · 2014 to 2023
$3.8M
Validation of imaging brain tumor metabolism using deuterated glucoseR01EB033764 · NIBIB · YALE UNIVERSITY · PI ROBIN A DE GRAAF, Henk De Feyter · 2023 to 2026
$2.4M
Drinking, Brain Acetate, and StressR01AA031401 · NIAAA · YALE UNIVERSITY · PI Graeme F Mason · 2024 to 2026
$2.0M
Time-efficient MRI and deuterium metabolic imaging (DMI) through parallel signal acquisitionR01EB034730 · NIBIB · YALE UNIVERSITY · PI ROBIN A DE GRAAF · 2024 to 2026
$1.4M
Single-scan, multi-contrast imaging of glucose metabolism in patients with glioblastomaR01CA288833 · NCI · YALE UNIVERSITY · PI Henk De Feyter · 2025 to 2026
$1.4M
Mapping of choline uptake and metabolism in brain tumors with deuterium metabolic imaging (DMI)R03CA267438 · NCI · YALE UNIVERSITY · PI DE FEYTER, HENK · 2023 to 2024
$168k
National Cancer Center R01-CA288833National Cancer Center R03-CA267438NCI NIH HHS R01 CA288833NCI NIH HHS R03 CA267438NIAAA NIH HHS R01 AA031401NIAAA NIH HHS R01-AA031401NIBIB NIH HHS R01 EB025840NIBIB NIH HHS R01-EB025840NIBIB NIH HHS R01 EB033764NIBIB NIH HHS R01-EB033764NIBIB NIH HHS R01 EB034730NIBIB NIH HHS R01-EB034730NIDDK NIH HHS R01 DK101984NIDDK NIH HHS R01-DK101984
6 · The paper itself

Abstract

objectiveQuantitative Deuterium Metabolic Imaging, or DMI, is typically based on the natural abundance deuterium ( MATERIALS AND

methodsAn NMR method is presented to quantitatively and robustly determine the

resultsThe double ratio method is validated on samples with known DISCUSSION: The presented double ratio method is a robust and practical tool to determine

Indexed as

DeuteriumWaterAcetatesDimethyl SulfoxideDrinking WaterGlucoseHumansMagnetic Resonance SpectroscopyReproducibility of ResultsUnited StatesAcetatesDeuteriumDimethyl SulfoxideDrinking WaterGlucoseWaterDeuteriumDeuterium metabolic imaging (DMI)PlasmaWater

Identifiers

PMID41553451
PMCPMC12884391

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.