Evidence map›Paper›PMID 41553432›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Successful treatment of severe, refractory polyomavirus disease with partially HLA-matched donor-derived BKPyV-specific T cells in a pediatric kidney recipient.

Wibke Schumacher, Sophie Haumann, Lisa Eifler, Pablo Landgraf, André Oberthuer, Max Krause, Veronica Di Cristanziano, Britta Eiz-Vesper, Britta Maecker-Kohlhoff, Lutz T Weber and 1 more

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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wibke SchumacherFaculty of Medicine, Children's and Adolescents' Hospital, University Hospital of Cologne, University of Cologne, Cologne, Germany. wibke.schumacher@uk-koeln.de.ORCID http://orcid.org/0000-0003-0277-8070
Sophie HaumannFaculty of Medicine, Children's and Adolescents' Hospital, University Hospital of Cologne, University of Cologne, Cologne, Germany.
Lisa EiflerFaculty of Medicine, Children's and Adolescents' Hospital, University Hospital of Cologne, University of Cologne, Cologne, Germany.
Pablo LandgrafFaculty of Medicine, Children's and Adolescents' Hospital, University Hospital of Cologne, University of Cologne, Cologne, Germany.
André OberthuerFaculty of Medicine, Children's and Adolescents' Hospital, University Hospital of Cologne, University of Cologne, Cologne, Germany.
Max KrauseDepartment of Human Genetics, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Veronica Di CristanzianoInstitute of VirologyNational Reference Center for Papilloma- and Polyomaviruses, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Britta Eiz-VesperInstitute of Transfusion Medicine and Transplant Engineering, CELL Laboratory and T-Cell Registry, Hannover Medical School, Hanover, Germany.
Britta Maecker-KohlhoffInstitute of Transfusion Medicine and Transplant Engineering, CELL Laboratory and T-Cell Registry, Hannover Medical School, Hanover, Germany.
Lutz T WeberFaculty of Medicine, Children's and Adolescents' Hospital, University Hospital of Cologne, University of Cologne, Cologne, Germany.
Sandra HabbigFaculty of Medicine, Children's and Adolescents' Hospital, University Hospital of Cologne, University of Cologne, Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BK polyomavirus-associated nephropathy is a significant therapeutic challenge in kidney transplant recipients, often leading to allograft dysfunction. We report on a 12-year-old male kidney transplant recipient with severe, biopsy-proven BK polyomavirus-associated nephropathy and concurrent JC polyomavirus (JCPyV)-associated neurological symptoms. Due to failure of standard therapy, adoptive transfer of partially HLA-matched, BK polyomavirus-specific T cells from the kidney donor was administered as rescue therapy. The intervention induced a rapid decline in both BK polyomavirus (BKPyV) and JCPyV viral loads. This virological response was accompanied by the resolution of neurological symptoms and stabilization of allograft function. This case indicates that donor-derived BK polyomavirus-specific T cells represent a viable therapeutic modality for severe, refractory polyomavirus disease.

Indexed as

Adoptive TransferBK VirusJC VirusKidney DiseasesKidney TransplantationPolyomavirus InfectionsT-LymphocytesTumor Virus InfectionsChildHumansMaleTreatment OutcomeViral LoadBK polyomavirusBKV-associated nephropathyJC polyomavirusVirus-specific T cells

Identifiers

PMID41553432
PMCPMC13167845

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.