ArticleAnalytical and bioanalytical chemistry2026
Tackling matrix effects in biosensor-based analysis of untreated blood plasma.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Clinical Laboratory Innovations: Nanoscale Detection of Chloramphenicol Using Nanomaterial Biosensors.Analytical science advances · 2026Review
- Recent Progress in Artificial Intelligence in Biosensor Development: From Bioprobe Design to Fabrication and Signal Analysis.Biosensors · 2026Review
- Epitope-Imprinted Polymers for Selective Recognition of Bacterial Proteins: From Design to Analytical Applications.ACS measurement science au · 2026Review
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Authors and funding
3 authors.
Funding
Abstract
Human blood plasma is the matrix of choice for clinical diagnostic applications. However, matrix effects associated with its complex composition interfere with the accurate detection of biomarkers that are often present at extremely low concentrations. This study investigates such matrix effects, particularly the nonspecific adsorption of blood plasma to the sensor surface and the interaction of endogenous antibodies with the used receptors, and shows how they can be discriminated using a surface plasmon resonance biosensor. Moreover, we describe a strategy to tackle matrix effects by combining sequential blood plasma/buffer injections, single-surface referencing, and the addition of an antibody against endogenous immunoglobulins to blood plasma. Finally, we apply this strategy to the detection of the cancer biomarker carcinoembryonic antigen in undiluted blood plasma, achieving detection limits of 12 ng/mL using direct detection, and 225 pg/mL using a sandwich assay with functional gold nanoparticles.
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Registered trials
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