Evidence map›Paper›PMID 41553324›Full record

ArticleJACC. Case reports2026

Valvular and Outflow Tract Metastases From Germ Cell Tumors: Contrasting Left-Sided Embolism and Right-Sided Silence.

Enrique Ruiz-Mori, Alfonso Gonzalez-Trejo, Ana K Nieto-Dolores, Hugo A Valencia-Hernandez, Leonor E Ayala-Bustamante, Mauricio Garcia-Cardenas, Enrique C Guerra, Camila Ponce-Acosta, Gilberto H Acosta-Gutierrez, Nilda Espinola-Zavaleta

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Enrique Ruiz-MoriDepartment of Cardiology, National Institute of Neoplastic Diseases, Lima, Peru; Department of Cardio-oncology, National Institute of Neoplastic Diseases, Lima, Peru; San Martin Porres University, Santa Anita, Peru.
Alfonso Gonzalez-TrejoFaculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
Ana K Nieto-DoloresFaculty of Medicine, Popular Autonomous University of Puebla, Puebla, Mexico.
Hugo A Valencia-HernandezFaculty of Medicine, Villa Rica University, Veracruz, Mexico.
Leonor E Ayala-BustamanteDepartment of Cardio-oncology, National Institute of Neoplastic Diseases, Lima, Peru.
Mauricio Garcia-CardenasDepartment of Cardio-oncology, National Institute of Neoplastic Diseases, Lima, Peru.
Enrique C GuerraMD-PhD (PECEM) Program, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
Camila Ponce-AcostaMexican Faculty of Medicine, La Salle University, Mexico City, Mexico.
Gilberto H Acosta-GutierrezInstitute of Biomedical Science, Autonomous University of Juarez City, Nuevo Casas Grandes, Chihuahua, Mexico.
Nilda Espinola-ZavaletaDepartment of Nuclear Cardiology, National Institute of Cardiology Ignacio Chavez, Mexico City, Mexico; Department of Echocardiography, ABC Medical Center, Mexico City, Mexico. Electronic address: niesza2001@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNonseminomatous testicular germ cell tumors (TGCTs) rarely metastasize to the heart, posing cardiovascular diagnostic and management challenges. CASE SUMMARY: We present 2 young men (20 and 28 years) with advanced mixed TGCTs. One developed acute ischemic stroke and myocardial infarction, the other a multifocal murmur. Both showed elevated alpha-fetoprotein, beta human chorionic gonadotropin, and pulmonary nodules. Transthoracic echocardiography revealed atrioventricular valves and outflow tract masses. DISCUSSION: In TGCT, embolic or new cardiovascular findings should prompt urgent transthoracic echocardiography to assess cardiac metastases. Early multimodality imaging can uncover silent disease and guide timely multidisciplinary care. Management focuses on definitive tumor resection and platinum-based chemotherapy. TAKE-HOME MESSAGES: Cardiac metastases from testicular cancer may first present with neurological or cardiovascular symptoms. Right-sided secondary cardiac tumors may be silent, whereas left-sided involvement may cause embolic events.

Indexed as

cardiac metastasisgerm cell tumorstroketesticular cancertransthoracic echocardiography

Identifiers

PMID41553324
PMCPMC12948568

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.