ArticleInternational journal of cancer2026
No relevant pharmacokinetic interaction between the KRAS G12C inhibitor sotorasib and the direct oral anticoagulant rivaroxaban in healthy subjects.
Article in International journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Cancer patients have an increased risk of thromboembolic events. Consequently, anticoagulants such as rivaroxaban are often prescribed. With the increasing use of targeted therapies, there is a growing concern about potential drug-drug interactions, as these therapies can affect metabolic enzymes and transporters (i.e., cytochrome P450 3A and P-glycoprotein). When used in combination with rivaroxaban, these interactions may elevate a patient's risk of thromboembolic events or bleeding. Our primary objective was to investigate the effect of sotorasib on the pharmacokinetics of rivaroxaban and determine the safety of this combination in healthy volunteers. In an open label, single-sequence, pharmacokinetic drug-drug interaction study in healthy subjects, the influence of a once-daily 960 mg dose sotorasib for a period of 14 days was evaluated on the pharmacokinetics of a single 20 mg dose rivaroxaban. This clinical study followed the FDA guidance on drug interaction studies. A clinically relevant pharmacokinetic interaction was considered absent if the 90% confidence intervals (CIs) of the geometric mean ratios for C
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