Evidence map›Paper›PMID 41552850›Full record

ArticlePest management science2026

A new method to measure EC

Firas Talas, Jessica Stapley, Bruce A McDonald

Abstract read
In one paragraph

Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Comprehensive analysis of the mechanisms conferring resistance to phenamacril in theFrontiers in cellular and infection microbiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Firas TalasPlant Pathology Group, Institute of Integrative Biology, ETH Zurich, Zürich, Switzerland.ORCID https://orcid.org/0000-0003-0942-7345
Jessica StapleyPlant Pathology Group, Institute of Integrative Biology, ETH Zurich, Zürich, Switzerland.
Bruce A McDonaldPlant Pathology Group, Institute of Integrative Biology, ETH Zurich, Zürich, Switzerland.

Funding

Eidgenössische Technische Hochschule Zürich
6 · The paper itself

Abstract

backgroundZymoseptoria tritici causes Septoria tritici blotch (STB), the most damaging wheat disease in Europe. In Europe, STB is controlled mainly by fungicides and fungicide resistance is frequently reported. Although fungicide resistance is thought to emerge mainly from standing genetic variation within field populations of Z. tritici, few studies have attempted to quantify the degree of fungicide resistance occurring at the field scale and to measure changes in the frequencies of resistant strains following fungicide applications during a single growing season. Even fewer studies have considered the effects of different wheat cultivars on the emergence of fungicide resistance. We developed a new high-throughput method based on resazurin dye and image analysis to measure the effective concentration of a fungicide that reduces growth by 50% (EC

resultsWe found that field populations of Z. tritici can maintain a very high diversity in fungicide sensitivity phenotypes despite three fungicide treatments, with as much diversity found within a single field during a single growing season as has been described across all of Europe over several years. We discovered that wheat cultivars that were more resistant to STB tended to be colonized by Z. tritici strains that exhibited higher fungicide resistance. We also found that specific wheat cultivars selected for resistance to specific active ingredients, providing the first direct support for the existence of significant host-fungicide-pathogen interactions.

conclusionOverall, our findings illustrate the many challenges associated with designing fungicide treatment programs that aim to reduce selection for fungicide resistance when confronted with a pathogen like Z. tritici that has a very high evolutionary potential. © 2026 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Indexed as

AscomycotaDrug Resistance, FungalFungicides, IndustrialTriticumGenetic VariationPlant DiseasesFungicides, IndustrialEC50host–fungicide–pathogen interactionsresazurinSeptoria tritici blotch

Identifiers

PMID41552850
PMCPMC12976203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.