Evidence map›Paper›PMID 41552838›Full record

ReviewInternational journal of cancer2026

Predicting optimal impact interventions in the post-HPV vaccination world.

Matti Lehtinen, Marc Lipsitch, Ville N Pimenoff, Karin Sundström, Johannes Berkhof, Iacopo Baussano, Simopekka Vänskä, Joakim Dillner

Abstract readReview
In one paragraph

Review in International journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matti LehtinenCentre for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-9481-0535
Marc LipsitchDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, USA.ORCID https://orcid.org/0000-0003-1504-9213
Ville N PimenoffResearch Unit of Population Health, Faculty of Medicine, Oulu University, Oulu, Finland.ORCID https://orcid.org/0000-0002-0813-7031
Karin SundströmCentre for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-6865-0224
Johannes BerkhofDepartment of Epidemiology and Data Science, Amsterdam University Medical Centers, Location VUMC, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0003-2094-2380
Iacopo BaussanoEarly detection, Prevention and Infections Branch, International Agency for Research on Cancer, Lyon, France.
Simopekka VänskäInfectious Disease Control & Vaccinations, Finnish Institute for Health & Welfare, National Institute for Health & Welfare, Helsinki, Finland.ORCID https://orcid.org/0000-0002-5677-721X
Joakim DillnerCentre for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.ORCID https://orcid.org/0000-0001-8588-6506

Funding

World Health Organization 001
6 · The paper itself

Abstract

Prophylactic vaccination is a powerful tool that changes exposure to infections and associated morbidity of preventable diseases. We discuss the impact of pneumococci and human papillomavirus (HPV) vaccination on the population biology of the two micro-organisms and related public health effects. Data on HPV type-replacement in communities where vaccine-covered HPVs are almost eliminated, and interactions of the remaining HPV types on the risk of cervical cancer are reviewed. Results of comprehensive models for European country-specific conduction of cervical screening among HPV-vaccinated and unvaccinated women, assuming different HPV-vaccination coverage and strategies, are discussed in our policy-oriented review. An acceptable balance of benefits and harms of cervical cancer screening in HPV vaccinated populations requires an understanding of cancer risks in differently vaccinated birth cohorts. Finally, the challenges are complex but can be met if strategies are applied that (i) as fast as possible achieve herd effect and (ii) use a risk-based design of HPV screening.

Indexed as

Human Papillomavirus VirusesPapillomavirus InfectionsPapillomavirus VaccinesUterine Cervical NeoplasmsEarly Detection of CancerFemaleHumansPneumococcal VaccinesVaccinationPapillomavirus VaccinesPneumococcal Vaccinescervical cancerhuman papillomavirusscreeningtype‐replacementvaccination

Identifiers

PMID41552838
PMCPMC12963704

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.