Evidence map›Paper›PMID 41552834›Full record

ArticlePNAS nexus2026

A sulfotransferase from a gut microbe acts on diverse phenolic sulfate compounds, including acetaminophen sulfate.

Rylee Close, Schuyler Kremer, Madison Mitchem, Andrew Bellinghiere, Khemlal Nirmalkar, Chad R Borges, Rosa Krajmalnik-Brown, Dhara D Shah

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rylee CloseBiodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ 85281, USA.
Schuyler KremerBiodesign Center for Personalized Diagnostics, Arizona State University, Tempe, AZ 85281, USA.ORCID https://orcid.org/0009-0001-2232-0828
Madison MitchemBiodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ 85281, USA.
Andrew BellinghiereBiodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ 85281, USA.ORCID https://orcid.org/0009-0000-5526-911X
Khemlal NirmalkarBiodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ 85281, USA.ORCID https://orcid.org/0000-0001-6732-9175
Chad R BorgesBiodesign Center for Personalized Diagnostics, Arizona State University, Tempe, AZ 85281, USA.ORCID https://orcid.org/0000-0002-8122-3438
Rosa Krajmalnik-BrownBiodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ 85281, USA.ORCID https://orcid.org/0000-0001-6064-3524
Dhara D ShahBiodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ 85281, USA.ORCID https://orcid.org/0000-0002-7533-7586

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sulfonation is one of the two main phase II detoxification pathways in eukaryotes which transforms nonpolar compounds into hydrophilic metabolites. Sulfotransferases catalyze these reactions by transferring a sulfo group from a donor to an acceptor molecule. Human cytosolic sulfotransferases use only 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor to sulfonate a variety of chemicals. Less understood are microbial aryl-sulfate sulfotransferases (ASSTs), which catalyze sulfo transfer reactions, without utilizing PAPS as a donor. Currently, the identity of physiological sulfo donor substrates remains unknown and sulfo acceptor substrates are underexplored. With this study, we aim to understand the potential contribution of a gut microbial enzyme to sulfonation chemistry by uncovering its substrate preferences. Here, we show that a sulfotransferase (

Indexed as

acetaminophenbacteroidesgut microbiomep-cresolsulfotransferase

Identifiers

PMID41552834
PMCPMC12809581

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.