Evidence map›Paper›PMID 41552820›Full record

ArticleFrontiers in pharmacology2025

Sajad Fakhri, Mohammad Mehdi Gravandi, Mohammad Bagher Majnooni, Mohammad Hosein Farzaei, Fatemeh Abbaszadeh, Khodabakhsh Rashidi, Javier Echeverría

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sajad Fakhri *Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Mohammad Mehdi Gravandi *Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Mohammad Bagher MajnooniPharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Mohammad Hosein FarzaeiPharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Fatemeh AbbaszadehNeurobiology Research Center, Institute of Neuroscience and Cognition, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Khodabakhsh RashidiResearch Center of Oils and Fats, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Javier EcheverríaDepartamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Alzheimer's disease (AD), the most common form of dementia, significantly affects memory and behavior due to dysregulated pathways involving oxidative stress, inflammation, and opioidergic systems. Currently, no effective treatments are available, underscoring the need for novel alternatives. Purpose: This study investigates the anti-AD effects of Materials and methods: The aqueous extract, prepared by macerating powdered gum in distilled water for 48 h at ambient temperature, was subjected to phytochemical analysis using ultraviolet, infrared, and nuclear magnetic resonance spectroscopy. Thirty rats were assigned to five different groups: one receiving saline, one receiving AlCl Results and discussion: The phytochemical analysis of FAGAE revealed the presence of polysaccharide compounds with tentative arabinogalactan structures. FAGAE decreased step-through latency in the passive avoidance test and modified AlCl Conclusion: Behavioral, biochemical, and histopathological impairments induced by AlCl

Indexed as

aluminum chlorideAlzheimer’s diseaseaqueous extractFerula ammoniacum gumneuroprotectionopioidergic pathwayoxidative stress

Identifiers

PMID41552820
PMCPMC12808390

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.