Evidence map›Paper›PMID 41552764›Full record

ArticleClinical and translational radiation oncology2026

Vestibular dose predicts toxicity in stereotactic radiosurgery for vestibular schwannomas.

Dimitrios Daskalou, Edouard Romano, Sophie Neveü, Pelagia Tsoutsou, Nikolaos Koutsouvelis, Francis Rousset, Nils Guinand, Minerva Becker, Pascal Senn, Sebastien Tran

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In one paragraph

Article in Clinical and translational radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dimitrios DaskalouService of Otorhinolaryngology-Head and Neck Surgery, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland.
Edouard RomanoDepartment of Radiation Oncology, University Hospitals of Geneva, Geneva, Switzerland.
Sophie NeveüDepartment of Diagnostic Radiology, University Hospitals of Geneva, Geneva, Switzerland.
Pelagia TsoutsouDepartment of Radiation Oncology, University Hospitals of Geneva, Geneva, Switzerland.
Nikolaos KoutsouvelisDepartment of Radiation Oncology, University Hospitals of Geneva, Geneva, Switzerland.
Francis RoussetThe Inner Ear and Olfaction Lab, University of Geneva, Faculty of Medicine, Geneva, Switzerland.
Nils GuinandService of Otorhinolaryngology-Head and Neck Surgery, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland.
Minerva BeckerDepartment of Diagnostic Radiology, University Hospitals of Geneva, Geneva, Switzerland.
Pascal SennService of Otorhinolaryngology-Head and Neck Surgery, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland.
Sebastien TranDepartment of Radiation Oncology, University Hospitals of Geneva, Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Stereotactic radiosurgery (SRS) provides excellent tumor control in small and medium vestibular schwannomas (VS), but its impact on the vestibular system remains uncertain. This study examines the effects of SRS on subjective vestibular symptoms, vestibular function, and potential predictors of symptom worsening. Materials and methods: A retrospective analysis was conducted on adult VS patients treated with SRS over eight years. Vestibular symptoms were graded at baseline and six months post-SRS. The vestibular sensory organs (VSO) were defined as the combined volume of the saccule, utricle, and ampullae. Vestibular function was assessed with bithermal, bilateral caloric testing, video head impulse testing, and vestibular evoked myogenic potentials. Two illustrative treatment plans were generated to assess feasibility of vestibular dose reduction without compromising planning target volume (PTV) or cochlear constraints. Results: Among 45 VS patients (median age 61.4 years), 14 (31 %) reported worsened vestibular symptoms at six months. These patients had higher Dose Conclusion: Higher vestibular radiation dose is strongly associated with worsened vestibular symptoms and possibly with functional decline. Dose reduction to vestibular subunits is feasible without compromising the tumor dose, helping mitigate these effects.

Indexed as

Dosimetric optimizationInner earRadiosurgeryVestibular function testVestibular schwannomaVestibular symptoms

Identifiers

PMID41552764
PMCPMC12811486

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.