ArticleClinical and translational radiation oncology2026
Mini-GRID enhances survival and reduces toxicity in an orthotopic murine model of oral squamous cell carcinoma: A proof-of-concept study.
Article in Clinical and translational radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
- Erratum issued
Authors and funding
10 authors.
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Abstract
Background and purpose: Oral squamous cell carcinoma (OSCC) remains a major clinical challenge, with limited therapeutic options and poor outcomes. Among the emerging approaches to address this unmet need, spatially fractionated radiotherapy (SFRT) using mini-GRID patterns has emerged as a promising approach, delivering high radiation doses through narrowly collimated beamlets that spare intervening normal tissue and may enhance the therapeutic index. This study evaluated the efficacy and safety of mini-GRID RT in an orthotopic, syngeneic murine model of OSCC. Materials and methods: C57BL/6 mice bearing MOC1 tumors were randomized to receive conventional radiotherapy (conv-RT; 20 Gy), mini-GRID RT (20 Gy average dose), or no treatment. Endpoints included survival, tumor growth, body weight, and histopathological assessment of tumor and surrounding normal tissues. Results: Mini-GRID RT significantly extended median survival (56 days) compared with controls (36 days; Conclusion: These findings indicate that mini-GRID RT can improve survival while maintaining a favorable toxicity profile in OSCC, supporting its potential as a novel high-dose radiotherapy approach. Further studies are warranted to elucidate underlying mechanisms, including vascular and immune-mediated responses, and to assess its translational relevance in clinical practice.
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