Evidence map›Paper›PMID 41552750›Full record

ArticleResearch and practice in thrombosis and haemostasis2026

High-density lipoprotein subfractions and risk of future venous thromboembolism-the HUNT study.

Inga A Røstvold, Ben Brumpton, Kristian Hveem, Bjørn Olav Åsvold, Guro F Giskeødegård, George Davey Smith, Nicholas J Timpson, Kaitlin H Wade, John-Bjarne Hansen, Sigrid K Brækkan

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Article in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Inga A RøstvoldThrombosis Research Group (TREC), Department of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway.
Ben BrumptonHUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Kristian HveemHUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Bjørn Olav ÅsvoldHUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Guro F GiskeødegårdDepartment of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
George Davey SmithMRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
Nicholas J TimpsonMRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
Kaitlin H WadeMRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
John-Bjarne HansenThrombosis Research Group (TREC), Department of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway.
Sigrid K BrækkanThrombosis Research Group (TREC), Department of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Previous studies on high-density lipoprotein (HDL) cholesterol levels and the risk of venous thromboembolism (VTE) have shown conflicting results, and it has been suggested that specific HDL subfractions and lipid composition may be more informative with regards to VTE risk. Objectives: We aimed to investigate the association between HDL subfractions (including particle size, concentration, and lipid composition) and risk of VTE in a population-based cohort. Methods: The study included 17,032 participants from the Trøndelag Health Study (HUNT3) cohort conducted in 2006-2008 who were followed up until December 31, 2019. HDL subfractions were analyzed in serum using nuclear magnetic resonance spectroscopy. All incident VTEs during follow-up were validated and recorded. Cox proportional hazards regression models estimated hazard ratios (HRs) for the association between HDL metrics and incident VTE, adjusting for age, sex, and body mass index. Results: During a median follow-up of 12.0 years, 342 incident VTE cases were confirmed. No associations were found among HDL particle size, HDL concentration, HDL lipid composition, apolipoprotein (Apo)A1 levels, and VTE risk. All HRs per 1-SD increase in HDL metrics were within the range of 0.83 to 1.16 and had 95% CIs that included 1. Furthermore, quartile analyses of HDL particles (Q4 vs Q1-HR, 0.89; 95% CI, 0.65-1.21) and ApoA1 (Q4 vs Q1-HR, 0.94; 95% CI, 0.68-1.29) showed no associations with VTE risk. Conclusion: HDL subfractions, including particle size, concentration, lipid composition, and ApoA1, were not associated with the risk of a first-lifetime VTE event.

Indexed as

cohort studiesdeep vein thrombosishigh-density lipoproteinpulmonary embolismvenous thrombosis

Identifiers

PMID41552750
PMCPMC12804113

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.