Evidence map›Paper›PMID 41552748›Full record

ArticleResearch and practice in thrombosis and haemostasis2026

Joint tissue plasticity in hemophilia: insights from the Joint Activity and Damage Exam ultrasound protocol.

Parthiv Sheth, Khang Tong, Bilgimol Chumappumkal Joseph, Tina Manon-Jensen, Michael Glenzer, Isaac Nwi-Mozu, Peter Aguero, Bruno Steiner, Cindy Bailey, Doris V Quon and 5 more

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Article in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Parthiv ShethDivision of Hematology/Oncology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Khang TongAltman Clinical and Translational Research Institute, University of California San Diego, La Jolla, California, USA.
Bilgimol Chumappumkal JosephDivision of Hematology/Oncology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Tina Manon-JensenNordic Biosciences, Herlev, Denmark.
Michael GlenzerDivision of Hematology/Oncology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Isaac Nwi-MozuDivision of Hematology/Oncology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Peter AgueroDivision of Hematology/Oncology, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Bruno SteinerWashington Center for Bleeding Disorders, Seattle, Washington, USA.
Cindy BaileyOrthopaedic Hemophilia Treatment Center, Orthopaedic Institute for Children Los Angeles, Los Angeles, California, USA.
Doris V QuonOrthopaedic Hemophilia Treatment Center, Orthopaedic Institute for Children Los Angeles, Los Angeles, California, USA.
Rebecca Kruse-JarresWashington Center for Bleeding Disorders, Seattle, Washington, USA.
Euyhyun LeeAltman Clinical and Translational Research Institute, University of California San Diego, La Jolla, California, USA.
Morten Asser KarsdalNordic Biosciences, Herlev, Denmark.
Lin LiuHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, California, USA.
Annette von DrygalskiDivision of Hematology/Oncology, Department of Medicine, University of California San Diego, La Jolla, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Progressive arthropathy is a debilitating condition that affects hemophilic joints as a consequence of hemarthroses. However, our understanding of the trajectory of potentially destructive processes at the tissue level remains limited and requires longitudinal imaging studies. Objectives: To longitudinally characterize ultrasonographic joint tissue changes in adults with hemophilia using the Joint Activity and Damage Exam (JADE) protocol, and to examine their relationships with joint health status, hemarthrosis, and serum biomarkers of tissue turnover. Methods: We prospectively studied adults with hemophilia (A or B) of any severity and associated arthropathy at 3 North American sites. We assessed joint health using the Hemophilia Joint Health Score (HJHS) and musculoskeletal ultrasound, as well as the Joint Activity and Damage Exam protocol for direct measurements of osteochondral alterations, cartilage, and soft tissue in the elbows, ankles, and knees at study entry and at ∼12 to 18 and ∼24 to 36 months thereafter. Reported hemarthrosis between study visits was verified by musculoskeletal ultrasound. We analyzed tissue rate changes in healthy (HJHS 0-3) and unhealthy (HJHS ≥ 4) joints, as well as in joints with and without hemarthrosis. Associations between tissue measurements and serially obtained serum biomarkers (C4M, PRO-C4, and C3M) were explored using logistic regression. Results: The median age ( Conclusion: Ultrasonographic tissue measurements discriminated between healthy and unhealthy joints at baseline. Measurements revealed a dynamic pattern of tissue plasticity not only in healthy but also in unhealthy and bleeding joints, suggesting potential for reversibility of often-assumed irreversible intra-articular damage in hemophilic joints.

Indexed as

biomarkerscartilagehemarthrosishemophiliaultrasonography

Identifiers

PMID41552748
PMCPMC12805341

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