ArticleCureus2026
Multiparametric Breast MRI for the Differentiation of Atypical Ductal Hyperplasia and Ductal Carcinoma In Situ in Postmenopausal Women.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Atypical ductal hyperplasia (ADH) is a proliferative epithelial breast lesion associated with an increased risk of progression to ductal carcinoma in situ (DCIS) or invasive carcinoma. Although breast MRI is highly sensitive for lesion detection, its ability to differentiate biologically related non-mass enhancement (NME) lesions such as ADH and DCIS remains incompletely defined. Aim The aim of this exploratory study was to investigate whether predefined morphologic, dynamic, and functional breast MRI parameters, such as lesion size, postcontrast signal intensity increase (wash-in), time-intensity curve (TIC) type, apparent diffusion coefficient (ADC), and positive enhancement integral (PEI), demonstrate measurable differences between ADH and DCIS in postmenopausal women. Materials and methods This retrospective, single-center study included 40 postmenopausal women with histopathologically confirmed ADH (n = 20) or DCIS (n = 20) who underwent standardized 1.5-Tesla (T) breast MRI. Quantitative MRI parameters evaluated included lesion size, early postcontrast signal intensity increase (wash-in), time-intensity curve (TIC) type, apparent diffusion coefficient (ADC), and positive enhancement integral (PEI). Groups were matched for age and lesion size. Statistical comparisons were performed using appropriate parametric tests, with a two-sided significance threshold of p < 0.05. Results No statistically significant differences were observed between ADH and DCIS across the evaluated MRI parameters, including lesion size (p = 0.119), wash-in (p = 0.484), ADC (p = 0.141), or PEI (p = 0.360). TIC Types 1 and 2 were similarly distributed between groups (p = 0.342), with no lesions demonstrating a washout pattern. Conclusion In this exploratory cohort of postmenopausal women, ADH and DCIS demonstrated substantial overlap in morphologic, dynamic, and functional breast MRI parameters. While no statistically significant differences were identified, these findings should be interpreted cautiously given the limited sample size and potential for Type II error. Larger, adequately powered studies incorporating advanced quantitative imaging techniques are required to determine whether multiparametric MRI can reliably differentiate between these entities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.