ArticleCureus2026
Breast MRI in the Assessment of Internal Thoracic Lymph Nodes: Morphodynamic and Functional Criteria for Detection of Metastatic Lymph Nodes.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
introductionMetastasis to internal thoracic artery lymph nodes (ITLNs) occurs in a substantial proportion of patients with breast carcinoma and is associated with adverse prognosis. Despite its clinical importance, standardized imaging criteria for ITLN assessment are lacking. This study aimed to evaluate morphological and functional MRI features that differentiate metastatic from physiological ITLNs in breast cancer patients.
methodsIn this retrospective single-center study, 34 patients with histologically confirmed invasive breast carcinoma and detectable ITLNs on breast MRI were included. Sixteen patients had metastatic ITLNs (confirmed histologically or by fluorodeoxyglucose positron emission tomography), while 18 patients had non-metastatic ITLNs with imaging stability on follow-up. All patients underwent breast MRI, including dynamic contrast-enhanced (DCE)-MRI and diffusion-weighted imaging (DWI). Morphological parameters (short axis, long axis, short-to-long axis ratio, volume, surface area, and compactness) and functional parameters (apparent diffusion coefficient (ADC) and positive enhancement integral (PEI)) were analyzed and compared between groups.
resultsMetastatic ITLNs demonstrated significantly larger short and long axis diameters, greater volume and surface area, lower compactness, and significantly lower ADC values compared with non-metastatic ITLNs (all p < 0.0001). The short-to-long axis ratio and PEI showed smaller differences between groups and were less discriminatory. The ADC values were significantly lower in metastatic ITLNs, reflecting increased cellularity. Cut-off values for multiple parameters demonstrated high diagnostic performance, with sensitivities and specificities exceeding 90%.
conclusionsMorphological MRI parameters, particularly lymph node size, volume, surface area, compactness, and ADC values, provide reliable criteria for distinguishing metastatic from physiological ITLNs in breast cancer patients. Incorporation of these morpho-functional MRI features into routine breast MRI assessment may improve diagnostic accuracy and staging. Larger prospective multicenter studies are warranted to validate these findings and establish standardized imaging protocols.
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