Evidence map›Paper›PMID 41552695›Full record

ArticleAdvanced synthesis & catalysis2024

Synthesis of 4,6-Difluoro-Tryptophan as a Probe for Protein

Christina M Monnie, Iker Hernández, Raixie Meléndez-Pacheco, Fatema Bhinderwala, Vadim A Soloshonok, Angela M Gronenborn, Aitor Landa, Mikel Oiarbide

Abstract read
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In one paragraph

Article in Advanced synthesis & catalysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Synthesis ofMagnetic resonance in chemistry : MRC · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christina M MonnieDepartment of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Ave., Pittsburgh, PA 15261, USA.
Iker HernándezDepartment of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizabal 3, 20018 Donostia-San Sebastián, Spain.
Raixie Meléndez-PachecoDepartment of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Ave., Pittsburgh, PA 15261, USA.
Fatema BhinderwalaDepartment of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Ave., Pittsburgh, PA 15261, USA.
Vadim A SoloshonokDepartment of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizabal 3, 20018 Donostia-San Sebastián, Spain.
Angela M GronenbornDepartment of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Ave., Pittsburgh, PA 15261, USA.
Aitor LandaDepartment of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizabal 3, 20018 Donostia-San Sebastián, Spain.
Mikel OiarbideDepartment of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizabal 3, 20018 Donostia-San Sebastián, Spain.

Funding

Project 3. IntegrationU54AI170791 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Peter Cherepanov · 2022 to 2026
$30.6M
NIAID NIH HHS U54 AI170791
6 · The paper itself

Abstract

A scalable procedure for the synthesis of 4,6-difluorotryptophan is reported based on a deaminative coupling of a 4,6-difluorogramine with 2-benzylthio-1,5-dihydro-4

Indexed as

Amino acid synthesisFluorinated tryptophansGramines couplingProtein 19F NMR

Identifiers

PMID41552695
PMCPMC12806166

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.