Evidence map›Paper›PMID 41552683›Full record

Trial reportFrontiers in cardiovascular medicine2025

Anthracycline-induced cardiotoxicity associated with myocardial energy metabolism: mechanisms revealed through an integration of

Yining Xu, Yihan Chen, Shujie Zhang, Biyun Zhang, Yao Zhu, Haiwen Ni, Weimin Jiang

Abstract readClinical Trial
In one paragraph

Trial report in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Early prediction of synergistic cardiotoxicity induced by PD-1 inhibitors and doxorubicin using cardiacChinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yining XuDepartment of Cardiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Yihan ChenDepartment of Cardiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Shujie ZhangDepartment of Cardiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Biyun ZhangDepartment of Nuclear Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Yao ZhuDepartment of Cardiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Haiwen NiDepartment of Hematology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Weimin JiangDepartment of Cardiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objectives: Anthracyclines, as a type of chemotherapy drugs, are widely used in the first-line treatment of cancers. However, anthracycline-induced cardiotoxicity (AIC) in the cumulative and dose-dependent manner greatly limits the clinical application. Insufficient energy supply caused by myocardial metabolic reconstruction is an established factor for AIC. At present, the left ventricular maximum standardized uptake value (LV SUV Methods: A total of 30 patients with diffuse large B-cell lymphomas and treated with anthracycline-based chemotherapy in the Hematology Department of Jiangsu Province Hospital of Chinese Medicine from December 2023 to December 2024 were enrolled. Finally, 17 participants were included as the Diffuse Large B-cell Lymphoma (DLBCL) group. Additionally, 13 non-oncologic participants without organic heart disease, who required Results: Among 17 patients in the DLBCL group, 6 received epirubicin chemotherapy with an average dose of 59.28 ± 12.54 mg/m Conclusion: An integration of Clinical Trial Registration: https://www.chictr.org.cn/, identifier ChiCTR2400088740.

Indexed as

18F-FDG PET/CTanthracyclinescardiotoxicityDIA proteomicsfatty acid oxidationglucose uptake

Identifiers

PMID41552683
PMCPMC12808406

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.