Evidence map›Paper›PMID 41552671›Full record

ArticleIJTLD open2026

Pharmacodynamic evidence for tedizolid use in

D Deshpande, S Srivastava, T Gumbo

Abstract read
In one paragraph

Article in IJTLD open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Novel regimens for treatment ofbioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

D DeshpandeBaylor University Medical Center, Dallas, TX, USA.
S SrivastavaBaylor University Medical Center, Dallas, TX, USA.
T GumboBaylor University Medical Center, Dallas, TX, USA.

Funding

Short course combination regimens for treatment of Mycobacterium avium pulmonary disease: a translational bench-to-bedside approachR01AI179827 · NIAID · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI Shashi Kant · 2024 to 2026
$1.7M
Reinforcing old warriors to treat Mycobacterium kansasii in shorter durationR21AI148096 · NIAID · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI KANT, SHASHI · 2020 to 2021
$413k
NIAID NIH HHS R01 AI179827NIAID NIH HHS R21 AI148096
6 · The paper itself

Abstract

objectiveOn guideline-based therapy for

designWe performed a 28-day study in the HFS-MAC inoculated with five different MAC isolates treated with six daily exposures, using intrapulmonary pharmacokinetics of tedizolid. Data were analysed using inhibitory sigmoid maximal effect (

resultsTedizolid killed the five clinical isolates of MAC with an

conclusionBased on the reported HFS-MAC studies using multiple clinical isolates of MAC, we propose that tedizolid at 200-300 mg/day should be tested as the backbone of novel combinations to treat MAC-LD.

Indexed as

hollow fibre systemMonte Carlo experimentsnon-TB mycobacteriapharmacodynamicspharmacokinetics

Identifiers

PMID41552671
PMCPMC12810753

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.