Evidence map›Paper›PMID 41552583›Full record

ReviewACS omega2026

Addressing Drug Delivery Failures: The Potential of Functionalized Nano/Microcapsules.

Roman Bielski, Donald Mencer, Zbigniew J Witczak

Abstract readReview
In one paragraph

Review in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Roman BielskiChemventive, LLC, Chadds Ford, Pennsylvania 19317, United States.ORCID https://orcid.org/0000-0003-1613-6917
Donald Mencer†Department of Pharmaceutical Sciences, Nesbitt School of Pharmacy; ‡Department of Chemistry & Biochemistry, Wilkes University, 84 W. South Street, Wilkes-Barre, Pennsylvania 18766, United States.
Zbigniew J Witczak†Department of Pharmaceutical Sciences, Nesbitt School of Pharmacy; ‡Department of Chemistry & Biochemistry, Wilkes University, 84 W. South Street, Wilkes-Barre, Pennsylvania 18766, United States.ORCID https://orcid.org/0000-0003-3310-6808

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It seems that often excellent drugs are not as effective as they could be due to huge losses of drug molecules before they reach the target destination. The present mini-review attempts to look at ways to address this acute issue, creating Ehrlich's "magic bullets", by utilizing functionalized nano/microparticles for drug delivery. These nano/microcapsules have moieties on the external surface that prevent the capsules from accumulating in the wrong places and facilitate their transport to the correct destination, piercing cell membranes and releasing the drug cargo into the cells. Importantly, the drug payload must not be in contact with the environment before reaching the target.

Identifiers

PMID41552583
PMCPMC12809337

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.