Evidence map›Paper›PMID 41552578›Full record

ReviewACS omega2026

Ionic Liquids in Pharmaceuticals: A Scoping Review of Formulation Strategies.

Igor Luiz Gonçalves Pereira, Ana Luiza Ziulkoski, Karine Modolon Zepon, Luiz Alberto Kanis, Henri Stephan Schrekker

Abstract readReview
In one paragraph

Review in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Topical pyridostigmine for ocular myasthenia gravis: a translational hypothesis.Medical hypothesis, discovery & innovation ophthalmology journal · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Igor Luiz Gonçalves PereiraInstitute of Chemistry, Laboratory of Technological Processes and Catalysis, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9500, 91501-970 Porto Alegre, RS, Brazil.
Ana Luiza ZiulkoskiInstitute of Health Sciences, Laboratory of Cytotoxicity, Universidade Feevale, RS-239, 2755, 93510-250 Novo Hamburgo, RS, Brazil.ORCID https://orcid.org/0000-0003-0850-4003
Karine Modolon ZeponUniversidade do Sul de Santa Catarina, Ciências da Saúde, Av. José Acácio Moreira, 787, 88704-900 Tubarão, SC, Brazil.
Luiz Alberto KanisAirela Indústria Farmacêutica Ltda., SC-390, 500, 88720-000 Pedras Grandes, SC, Brazil.
Henri Stephan SchrekkerInstitute of Chemistry, Laboratory of Technological Processes and Catalysis, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9500, 91501-970 Porto Alegre, RS, Brazil.ORCID https://orcid.org/0000-0002-8173-3841

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ionic liquids (ILs) have rapidly emerged as multifunctional formulation tools capable of addressing long-standing challenges in drug delivery. This scoping review systematically assessed their pharmaceutical applications through a structured search of Scopus, PubMed, and Web of Science, yielding 1866 records, of which 91 experimental studies met the inclusion criteria. Across oral, injectable, topical, transdermal, nasal, and advanced delivery systems, ILs consistently improved the drug solubility, chemical stability, mucosal permeability, and overall biopharmaceutical performance. Choline- and imidazolium-based ILs were the most frequently investigated, demonstrating favorable safety profiles and significant pharmacokinetic benefitsincluding increases in maximum plasma concentration (

Identifiers

PMID41552578
PMCPMC12809528

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.