Evidence map›Paper›PMID 41552522›Full record

ArticleACS omega2026

Contribution to the Chemotherapy of Human Trypanosomiasis: Design, Synthesis, and Biological Evaluation of Dimeric 2‑Nitroimidazoles against

Afonso Santine M M Velez, Otávio Augusto Chaves, Carlos Serpa, Fatma M Salem, Bibo Li, Bin Su, Célio Geraldo Freire-de-Lima, Debora Decote-Ricardo, Marco Edilson Freire de Lima

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Afonso Santine M M VelezPrograma de Pós-graduação Em Química, Instituto de Química, Universidade Federal Rural Do Rio de Janeiro, Seropédica, Rio de Janeiro 23.897-000, Brazil.ORCID https://orcid.org/0000-0002-7188-833X
Otávio Augusto ChavesDepartment of Chemistry, Coimbra Chemistry Center - Institute of Molecular Science (CQC-IMS), University of Coimbra, Rua Larga, Coimbra 3004-535, Portugal.ORCID https://orcid.org/0000-0001-6211-7659
Carlos SerpaDepartment of Chemistry, Coimbra Chemistry Center - Institute of Molecular Science (CQC-IMS), University of Coimbra, Rua Larga, Coimbra 3004-535, Portugal.ORCID https://orcid.org/0000-0001-7004-0110
Fatma M SalemDepartment of Chemistry, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
Bibo LiDepartment of Biology, Geo. & Env. Sciences, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
Bin SuDepartment of Chemistry, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.ORCID https://orcid.org/0000-0002-0711-441X
Célio Geraldo Freire-de-LimaInstituto de Biofísica Carlos Chagas Filho, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro 21.941-902, Brazil.
Debora Decote-RicardoDepartamento de Microbiologia E Imunologia Veterinária, Instituto de Veterinária - Universidade Federal Rural Do Rio de Janeiro, Seropédica, Rio de Janeiro 23897-035, Brazil.
Marco Edilson Freire de LimaPrograma de Pós-graduação Em Química, Instituto de Química, Universidade Federal Rural Do Rio de Janeiro, Seropédica, Rio de Janeiro 23.897-000, Brazil.ORCID https://orcid.org/0000-0003-0563-3483

Funding

Essential functions of Trypanosoma brucei RAP1R01AI179972 · NIAID · CLEVELAND STATE UNIVERSITY · PI Bibo Li · 2024 to 2026
$1.3M
NIAID NIH HHS R01 AI179972
6 · The paper itself

Abstract

Effective and safe treatments for neglected tropical diseases caused by parasites, such as Chagas disease and sleeping sickness, remain lacking, posing a significant challenge for researchers worldwide. The rational design of dimeric compounds inspired solely by the pharmacophoric core of benznidazole (2-nitroimidazole) has proven to be a promising strategy for antiparasitic development. Thus, in the present work, it was increased the linker between the active units (2-nitroimidazole) to improve the interaction with TcNTR, facilitating the bioactivation of the longest dimers. Biological assays confirmed this, demonstrating that all compounds were active against replicative intracellular amastigotes of

Identifiers

PMID41552522
PMCPMC12809571

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.