ArticleACS omega2026
Experimental Optimization of a Plasmonic Surface Biofunctionalization, toward the Bimodal Biosensing and Kinetic Characterization of sPD1.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Molecular states and interfacial interactions at solid-liquid interfaces: advances and challenges in multimodal characterization.Beilstein journal of nanotechnology · 2026Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Soluble PD1 (sPD1) plays a complex role in cancer pathophysiology, reportedly dependent on its interactions with immune checkpoint proteins and therapeutic monoclonal antibodies. Yet, no biosensor platform currently affords simultaneous quantification and kinetic profiling of sPD1-antibody interactions. Here, we introduce a surface plasmon resonance (SPR) refractometric biosensor setup functionalized with nivolumab that integrates direct, label-free quantification and real-time functional analysis of sPD1 in a buffer and human serum. Sensor functionalization strategies and robust regeneration protocols were investigated and optimized. The biosensor achieved a limit of detection of 5 ng/mL (limit of quantification (LOQ) 8.7 ng/mL; dynamic range 8.7 ng/mL to 376 μg/mL) and quantified sPD1 with 93 ± 5% recovery in 1% serum and 62 ± 30% in 10% serum. Kinetic constants (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.