Evidence map›Paper›PMID 41552481›Full record

ArticleACS omega2026

Bioactive Glass-Inspired Coating for Implants via Plasma Electrolytic Oxidation: A Preclinical Approach to Enhance Bone Repair in Healing-Impaired Conditions Associated with Diabetes.

Stéfany Barbosa Alves da Cruz, Raphael Cavalcante Costa, Francieli da Silva Flores, Maria Helena R Borges, Doris Hissako Matsushita, Martinna Bertolini, Nilson Cristino da Cruz, João Gabriel S Souza, Edilson Ervolino, Valentim A R Barão and 1 more

Abstract read
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In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stéfany Barbosa Alves da CruzDepartment of Diagnosis and Surgery, Dentistry School, Universidade Estadual Paulista (UNESP), Araçatuba 16015-050, São Paulo, Brazil.
Raphael Cavalcante CostaDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP), Piracicaba 13414-903, São Paulo, Brazil.
Francieli da Silva FloresDepartment of Diagnosis and Surgery, Dentistry School, Universidade Estadual Paulista (UNESP), Araçatuba 16015-050, São Paulo, Brazil.
Maria Helena R BorgesDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP), Piracicaba 13414-903, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-2132-4827
Doris Hissako MatsushitaDepartment of Basic Science, Dentistry School, Universidade Estadual Paulista (UNESP), Araçatuba 16015-050, São Paulo, Brazil.
Martinna BertoliniDepartment of Periodontics and Preventive Dentistry, University of Pittsburgh, Pittsburgh 15261, Pennsylvania, United States.
Nilson Cristino da CruzLaboratory of Technological Plasmas, Engineering College, Universidade Estadual Paulista (UNESP), Sorocaba 18087-180, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-0354-3890
João Gabriel S SouzaDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07023-070, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-5944-6953
Edilson ErvolinoDepartment of Basic Science, Dentistry School, Universidade Estadual Paulista (UNESP), Araçatuba 16015-050, São Paulo, Brazil.
Valentim A R BarãoDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP), Piracicaba 13414-903, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-6391-9917
Leonardo P FaveraniDepartment of Oral Diagnosis, Division of Oral and Maxillofacial Surgery, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP), Piracicaba 13414-903, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-2249-3048

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus is a globally prevalent metabolic disorder that impairs wound healing and bone regeneration, compromising outcomes in implant therapies that rely on osseointegration. Advances in precision medicine and bioengineering have driven the development of functionalized implant surfaces to overcome these limitations. Among them, bioactive glass (BG) coatings have emerged as promising candidates to enhance biological responses. Building upon this rationale, we unveiled the osteoinductive potential of a BG-based coating synthesized via plasma electrolytic oxidation (PEO) and its effects on peri-implant bone regeneration in a diabetic rat model. Titanium implants were treated with PEO using a formulation mimicking BG composition (∼45.0 Si, 24.5 Ca, 24.5 Na, 6.0 P; m/v %), and the resulting coating was characterized. Implants with a sandblasted and acid-etched (SLA) surface served as the control.

Identifiers

PMID41552481
PMCPMC12809862

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.