Sequential Formal (4 + 1)-Spirocycloaddition/Oxidative Cleavage between Indoles and

Nikolai A Arutiunov, Anna M Zatsepilina, Kirill V Tolstov, Daria A Shtal, Nicolai A Aksenov, Alexander V Aksenov

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Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Nikolai A ArutiunovDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355009, Russian Federation.ORCID https://orcid.org/0000-0003-2675-9093

Anna M ZatsepilinaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355009, Russian Federation.

Kirill V TolstovDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355009, Russian Federation.

Daria A ShtalDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355009, Russian Federation.

Nicolai A AksenovDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355009, Russian Federation.ORCID https://orcid.org/0000-0002-7125-9066

Alexander V AksenovDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355009, Russian Federation.ORCID https://orcid.org/0000-0002-6644-9949

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An effective protocol for the synthesis of benzamide-containing (3),4,5-substituted isoxazoles was developed. This one-pot procedure involved a formal (4 + 1)-spirocycloaddition between indoles and β-nitrostyrenes, followed by an oxidative cleavage with a mixture of acetic anhydride and hydrogen peroxide, which led to the formation of a highly functionalized isoxazole moiety. A total of 33 such compounds were synthesized in yields ranging from 44% to 91%, demonstrating good tolerance for various functional groups.

Identifiers

PMID41552476

DOI10.1021/acsomega.5c08724

PMCPMC12809815

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.