ArticleCHEST critical care2025
Protocol and Statistical Analysis Plan for the Vasopressin for Septic Shock Pragmatic (VASSPR) Cluster-Crossover Randomized Trial.
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Article in CHEST critical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06217562 (Vasopressin for Septic Shock Pragmatic Trial), which is not on this map. Cited by 1 paper.
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Vasopressin for Septic Shock Pragmatic Trial
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23 authors.
Ithan D PeltanDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Danielle GroatDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Jason R JacobsDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Elisabeth H TillmanDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Ben J BrintzDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Stephanie ChauvDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Sarah J BeesleyDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Jennifer H EdwardsDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Natalia ArizmendezDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Eliotte L HirshbergDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Jason R CarrDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Michael J LanspaDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Joseph R BledsoeDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Austin T SmithDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Harmony SchneiderDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Ping HuDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Tamara D Moores ToddDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Carolyn KlippelDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Matthew W SemlerDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Jonathan W CaseyDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Colin K GrissomDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Samuel M BrownDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Lindsay M LeitherDepartment of Pulmonary and Critical Care Medicine (I. D. P., D. G., J. R. J., E. H. T., S. J. B., J. H. E., N. A., E. L. H., J. R. C., M. J. L., C. K., C. K. G., S. M. B., and L. M. L.), the Department of Pharmacy (S. C. and H. S.), the Department of Emergency Medicine (J. R. B. and T. D. M. T.), Intermountain Medical Center, Murray, the Division of Epidemiology (B. J. B.), Department of Medicine, University of Utah; the Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine (E. L. H., C. K. G., and S. M. B.), Department of Medicine, University of Utah School of Medicine; Digital Technology Services (H. S., P. H., and T. D. M. T.), Intermountain Health, Salt Lake City; the Department of Emergency Medicine (A. T. S.), Park City Hospital, Park City, UT; the Division of Allergy, Pulmonary and Critical Care Medicine (M. W. S. and J. W. C.), Department of Medicine, and the Vanderbilt Institute for Clinical and Translational Research (M. W. S. and J. W. C.), Vanderbilt University Medical Center, Nashville, TN.
Funding
CTSA UM1 Program at University of UtahUM1TR004409 · NCATS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RACHEL HESS, Jennifer Juhl Majersik · 2023 to 2026
$21.9MNCATS NIH HHS UM1 TR004409
Abstract
backgroundGuidelines recommend vasopressin as the preferred second-line vasopressor for treatment of septic shock. However, the optimal threshold for vasopressin initiation is unclear. RESEARCH QUESTION: Does a treatment strategy using a lower or a higher threshold for initiation of vasopressin as a secondary vasopressor decrease the incidence of 28-day mortality for patients with septic shock? STUDY DESIGN AND
methodsThe Vasopressin for Septic Shock Pragmatic (VASSPR) trial is a multicenter, open-label, cluster-randomized, multiple cluster-crossover pragmatic clinical trial being conducted in 13 hospitals in Utah and Idaho. The trial compares a strategy for septic shock management recommending initiation of fixed-dose vasopressin as a secondary vasopressor at a lower threshold (when the total dose of other vasopressors reaches 0.1 mg/kg/min norepinephrine equivalents [NEEs]) to a strategy initiating vasopressin at a higher threshold (when other vasopressors reach 0.4 mg/kg/min NEEs). All adult patients with septic shock at study hospitals are enrolled in the trial and assigned to the treatment strategy in place at the study hospital when and where they start vasopressor treatment for suspected or confirmed septic shock. Individual patient care, including adherence to the assigned vasopressin initiation strategy, occurs at the discretion of each patient's treating clinicians. The primary outcome is 28-day all-cause mortality. The key secondary outcome is renal replacement therapy-free days to day 28.
resultsThis article describes the protocol and statistical analysis plan for the conduct and analysis of the VASSPR trial.
interpretationThe VASSPR trial will provide important data to guide vasopressor management for patients with septic shock. Prespecification of the trial protocol and statistical analysis plan before completion of enrollment is important for rigorous trial conduct and reporting. CLINICAL
trial registrationClinicalTrials.gov; No.: NCT06217562; URL: www.clinicaltrials.gov.
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cluster randomizationpragmatic clinical trialsepsisseptic shockvasopressinvasopressor therapy
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NCT06217562ClinicalTrials.gov
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