Cannonball metastases as an initial presentation of urothelial bladder carcinoma: a case report and literature review.

Karthik Rayapureddi, Michael Glover, Haiwei Henry Guo, Emily Chan, Sumit A Shah

Abstract readCase Reports

In one paragraph

Article in Urology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Karthik RayapureddiDepartment of Medicine - Division of Oncology, Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, CA, 94305, USA.

Michael GloverDepartment of Medicine - Division of Oncology, Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, CA, 94305, USA.

Haiwei Henry GuoDepartment of Radiology - Thoracic Imaging, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305, USA.

Emily ChanDepartment of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305, USA.

Sumit A ShahDepartment of Medicine - Division of Oncology, Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, CA, 94305, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urothelial carcinoma is the most common bladder cancer; although pulmonary spread occurs, cannonball metastases are rare and classically linked to germ cell and renal cell tumors. Bladder cancer typically presents with painless hematuria, so respiratory-only presentations can delay diagnosis. We report a 42-year-old man with progressive dyspnea and innumerable bilateral cannonball lesions as the initial manifestation of muscle-invasive urothelial carcinoma, without hematuria. To our knowledge, this is the first such initial presentation reported. This case underscore including urothelial carcinoma in the differential for pulmonary cannonball lesions and pursuing early biopsy and cystoscopic evaluation even in the absence of urinary symptoms.

Indexed as

Neoplasm metastasisPulmonary nodulesUrinary bladder neoplasms

Identifiers

PMID41552398

DOI10.1016/j.eucr.2025.103320

PMCPMC12811420

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