Evidence map›Paper›PMID 41552397›Full record

ArticleCell surface (Amsterdam, Netherlands)2026

Rho2-dependent cell wall remodeling boosts the fungistatic activity of manogepix against

Sean Brazil, Isabel Kopp-Fouquet, Samuel Zen Kai Yap, Michael Carty, Johannes Wagener

Abstract read
In one paragraph

Article in Cell surface (Amsterdam, Netherlands), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. New Perspectives on Antimicrobial Agents: Fosmanogepix.Antimicrobial agents and chemotherapy · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sean BrazilDepartment of Clinical Microbiology, School of Medicine, Trinity College Dublin, the University of Dublin, St James's Hospital Campus, Dublin, Ireland.
Isabel Kopp-FouquetDepartment of Clinical Microbiology, School of Medicine, Trinity College Dublin, the University of Dublin, St James's Hospital Campus, Dublin, Ireland.
Samuel Zen Kai YapDepartment of Clinical Microbiology, School of Medicine, Trinity College Dublin, the University of Dublin, St James's Hospital Campus, Dublin, Ireland.
Michael CartyDepartment of Clinical Microbiology, School of Medicine, Trinity College Dublin, the University of Dublin, St James's Hospital Campus, Dublin, Ireland.
Johannes WagenerDepartment of Clinical Microbiology, School of Medicine, Trinity College Dublin, the University of Dublin, St James's Hospital Campus, Dublin, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fosmanogepix is a new antifungal agent currently undergoing phase 3 clinical trials. Its active moiety, manogepix, inhibits Gwt1 which is an enzyme essential for the assembly and attachment of glycosylphosphatidylinositol anchors to cell wall proteins. Manogepix has a strong fungistatic activity against most human pathogenic fungal species. Here we characterized the activity of manogepix against the major human pathogenic mold

Indexed as

AntifungalsAspergillus fumigatusCell wallChitinFosmanogepixMidAResistanceRho2

Identifiers

PMID41552397
PMCPMC12807828

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.