ArticleAmerican journal of translational research2025
Efficacy and survival outcomes of bevacizumab plus minocycline for glioblastoma.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
objectiveTo evaluate the efficacy and survival outcomes of bevacizumab combined with minocycline versus bevacizumab monotherapy in patients with glioblastoma (GBM).
methodsWe conducted a retrospective analysis of 132 GBM patients treated at multiple centers between January 2022 and December 2023. Patients were divided into a control group (bevacizumab monotherapy, n = 67) and an observation group (bevacizumab plus minocycline, n = 65). Short-term treatment response, serum biomarkers, immune function, inflammatory and angiogenic factors, quality of life, safety, and long-term survival were assessed.
resultsThe observation group showed significantly higher objective response rate (53.85% vs. 29.85%) and disease control rate (78.46% vs. 61.19%), along with improved immune function, reduced inflammatory and angiogenic markers, and enhanced quality of life (all
conclusionThis retrospective analysis suggests that the combination of bevacizumab and minocycline is associated with promising efficacy in GBM patients, including improved objective response, survival, and quality of life, with a manageable safety profile. These findings support further evaluation in prospective randomized trials to confirm the therapeutic potential of this combination.
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