Evidence map›Paper›PMID 41552319›Full record

ArticleAmerican journal of translational research2025

Efficacy and safety of blood purification in the treatment of autoimmune encephalitis: a meta-analysis.

Minlu Wu, Mengmeng Wang, Wanning Li, Liyan Gu, Jie Wei, Jianhua Zhuang

Abstract read
In one paragraph

Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Minlu WuDepartment of Neurology, No. 905 Hospital of People's Liberation Army Navy Affiliated to Naval Medical University Shanghai 200052, China.
Mengmeng WangDepartment of Hyperbaric Oxygen and Neurology, Naval Medical Center Shanghai 200052, China.
Wanning LiDepartment of Neurology, No. 905 Hospital of People's Liberation Army Navy Affiliated to Naval Medical University Shanghai 200052, China.
Liyan GuDepartment of Neurology, No. 905 Hospital of People's Liberation Army Navy Affiliated to Naval Medical University Shanghai 200052, China.
Jie WeiDepartment of Neurology, No. 905 Hospital of People's Liberation Army Navy Affiliated to Naval Medical University Shanghai 200052, China.
Jianhua ZhuangDepartment of Neurology, The Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital) Shanghai 200003, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo systematically evaluate the efficacy and safety of blood purification in the treatment of autoimmune encephalitis (AE).

methodsDatabases including PubMed, Embase, and Cochrane Library were systematically searched. Prospective and retrospective cohort studies were included. Data on patients' baseline characteristics, interventions, and outcomes were extracted. The Newcastle-Ottawa Scale (NOS) was used to assess the quality of included studies. Meta-analysis was performed using RevMan 5.4 software.

resultsFifteen studies (531 patients) were included; NOS scores of 7-9 indicated high quality. Efficacy analysis showed that in studies with control groups, blood purification significantly increased the likelihood of clinical improvement (Odds Ratio (OR)=5.61, 95% Confidence Interval (CI) [2.72, 11.56],

conclusionBlood purification can significantly improve clinical outcomes in AE patients, but it is associated with higher risks of adverse events and relapse.

Indexed as

adverse reactionsautoimmune encephalitisBlood purificationefficacyhemoperfusionimmunoadsorptionmeta-analysisplasma exchangesafety

Identifiers

PMID41552319
PMCPMC12808021

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.